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While T\u2010DM1 demonstrates superior efficacy and tolerability, T\u2010DM1\u2010induced thrombocytopenia remains a significant adverse event leading to treatment discontinuation. To address this issue, the study investigates the feasibility of using poly(lactic\u2010co\u2010glycolic acid) (PLGA)\u00a0nanoparticles as a delivery vehicle to conjugate T\u2010DM1, aiming to alleviate T\u2010DM1\u2010induced thrombocytopenia. The T\u2010DM1\u2010conjugated PLGA nanoparticles (NPs\u2010T\u2010DM1) reduce binding to megakaryocytes without compromising the targeting ability for HER2. Administration of NPs\u2010T\u2010DM1 not only significantly inhibits tumor growth but also reduces damage to megakaryocytes, inhibits T\u2010DM1\u2010induced thrombocytopenia, and remarkably improves the safety of antibody\u2010conjugated drugs. This work presents a promising strategy to enhance the safety and efficacy of T\u2010DM1 in antitumor therapy, offering significant potential for advancing clinical application in HER2\u2010positive breast cancer patients.<\/jats:p>","DOI":"10.1002\/smll.202400977","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T05:21:12Z","timestamp":1728278472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enhancing the Safety and Efficacy of Trastuzumab Emtansine (T\u2010DM1) Through Nano\u2010Delivery System in Breast Cancer Therapy"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-7226","authenticated-orcid":false,"given":"Feiqi","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education Institute of Immunology The First Hospital of Jilin University  Changchun 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