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Unfortunately, there exists a significant shortage of high\u2010sensitivity and high\u2010resolution in vivo imaging techniques to fulfill this requirement. Herein, a contrast enhanced susceptibility\u2010weighted imaging (CE\u2010SWI) using the minimalist dextran\u2010modified Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoparticles (Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Dextran NPs) are introduced for the highly sensitive and high\u2010resolution AIS depiction under 9.4 T for the first time. The Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Dextran NPs are synthesized via a simple one\u2010pot coprecipitation method using commercial reagents under room temperature. It shows merits of small size (hydrodynamic size 25.8\u00a0nm), good solubility, high transverse relaxivity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    ) of 51.3 mM\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    at 9.4 T, and superior biocompatibility. The Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Dextran NPs\u2010enhanced SWI can highlight the cerebral vessels readily with significantly improved contrast and ultrahigh resolution of 0.1\u00a0mm under 9.4 T MR scanner, enabling the clear spatial identification of collateral circulation in the middle cerebral artery occlusion (MCAO) rat model. Furthermore, Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Dextran NPs\u2010enhanced SWI facilitates the precise depiction of ischemia core, collaterals, and ischemic penumbra post AIS through matching analysis with other multimodal MR sequences. The proposed Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @Dextran NPs\u2010enhanced SWI offers a high\u2010sensitivity and high\u2010resolution imaging tool for individualized characterization and personally precise theranostics of stroke patients.\n                  <\/jats:p>","DOI":"10.1002\/smll.202401061","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T09:47:00Z","timestamp":1720086420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Minimalist Iron Oxide Nanoprobe for the High\u2010Resolution Depiction of Stroke by Susceptibility\u2010Weighted Imaging"],"prefix":"10.1002","volume":"20","author":[{"given":"Bing","family":"Han","sequence":"first","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Key Laboratory of Digestive Cancer, National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital  Tianjin 300060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; Tianjin Institute of Radiology Tianjin Medical University General Hospital  Tianjin 300052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology The Second Hospital of Tianjin Medical University  Tianjin 300211 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging Tianjin Medical University  Tianjin 300203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohe","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Imaging, Tianjin Key Laboratory of Functional Imaging Tianjin Medical University  Tianjin 300203 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging &amp; 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