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Piezocatalytic therapy features high efficiency in generating reactive oxygen species (ROS) for tumor therapy, but it faces limitations in piezoelectricity and redox\u2010active site availability. Herein, Fe\u2010doped ultrathin Bi\n                    <jats:sub>4<\/jats:sub>\n                    Ti\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>12<\/jats:sub>\n                    nanosheets (designated as Fe\u2010UBTO NSs) with synergistically piezo\u2010chemocatalytic activity are engineered for antitumor and antibacterial treatment against cutaneous melanoma. The doping\u2010engineered strategy induces oxygen vacancies and lattice distortions in Fe\u2010UBTO NSs, which narrows bandgap to enhance piezocatalytic\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation by improving the electron\u2010hole pairs separation, hindering their recombination, and increasing oxygen adsorption. Moreover, Fe doping establishes a piezo\u2010chemocatalytic system, in which the piezocatalysis enables the self\u2010supply of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and expedites electron transfer in Fenton reactions, inducing increased \u00b7OH production. Besides, the atomic\u2010level thickness and expanded surface area enhance the sensitivity to ultrasound stimuli and expose more redox\u2010active sites, augmenting the piezo\u2010chemocatalytic efficiency, and ultimately leading to abundant ROS generation. The Fe\u2010UBTO\u2010mediated piezo\u2010chemocatalytic therapy causes intracellular oxidative stress, triggering apoptosis and excessive autophagy of tumor cells. Moreover, this strategy accelerates wound healing by facilitating sterilization, angiogenesis, and collagen deposition. This work provides distinct options to develop doping\u2010engineered ultrathin nanosheets with augmented piezo\u2010chemocatalytic activity for postoperative management of cutaneous melanoma.\n                  <\/jats:p>","DOI":"10.1002\/smll.202401171","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T09:17:36Z","timestamp":1717751856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Doping\u2010Engineered Piezoelectric Ultrathin Nanosheets for Synergistically Piezo\u2010Chemocatalytic Antitumor and Antibacterial Therapies Against Cutaneous Melanoma"],"prefix":"10.1002","volume":"20","author":[{"given":"Luxia","family":"Jing","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Zhongshan Hospital, Fudan University Shanghai Institute of Medical Imaging  Shanghai 200032 P. R. 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