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In this study, multimaterial\u2010printed serpentine microarchitectures are presented with synergistic mechanical\/piezoelectric stimulation, incorporating polycaprolactone (PCL) microfibers for mechanical support, polyvinylidene fluoride (PVDF) microfibers for piezoelectric stimulation, and magnetic PCL\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    for controlled deformation via an external magnet. Rat cardiomyocytes in piezoelectric constructs, subjected to dynamic mechanical stimulation, exhibit advanced maturation, featuring superior sarcomeric structures, improved calcium transients, and upregulated maturation genes compared to non\u2010piezoelectric constructs. Furthermore, these engineered piezoelectric cardiac constructs demonstrate significant structural and functional repair of infarcted myocardium, as evidenced by enhanced ejection and shortening fraction, reduced fibrosis and inflammation, and increased angiogenesis. The findings underscore the therapeutic potential of piezoelectric cardiac constructs for myocardial infarction therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202401561","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T03:42:20Z","timestamp":1718854940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Multimaterial Printing of Serpentine Microarchitectures with Synergistic Mechanical\/Piezoelectric Stimulation for Enhanced Cardiac\u2010Specific Functional Regeneration"],"prefix":"10.1002","volume":"20","author":[{"given":"Kang","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University  Xi'an 710049 P. R. 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