{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:55:13Z","timestamp":1792068913291,"version":"4.4.0"},"reference-count":75,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","award":["CFGFY20P14"],"award-info":[{"award-number":["CFGFY20P14"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH\u2010OFIRG21nov\u20100010"],"award-info":[{"award-number":["MOH\u2010OFIRG21nov\u20100010"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Atherosclerosis is the primary cause of cardiovascular events such as heart attacks and strokes. However, current medical practice lacks non\u2010invasive, reliable approaches for both imaging atherosclerotic plaques and delivering therapeutic agents directly therein. Here, a biocompatible and biodegradable pH\u2010responsive nanoscale coordination polymers (NCPs) based theranostic system is reported for managing atherosclerosis. NCPs are synthesized with a pH\u2010responsive benzoic\u2010imine (BI) linker and Gd\n                    <jats:sup>3+<\/jats:sup>\n                    . Simvastatin (ST), a statin not used for lowering blood cholesterol but known for its anti\u2010inflammatory and antioxidant effects in mice, is chosen as the model drug. By incorporating ST into the hydrophobic domain of a lipid bilayer shell on NCPs surfaces, ST\/NCP\u2010PEG nanoparticles are created that are designed for dual purposes: they diagnose and treat atherosclerosis. When administered intravenously, they target atherosclerotic plaques, breaking down in the mild acidic microenvironment of the plaque to release ST, which reduces inflammation and oxidative stress, and Gd\u2010complexes for MR imaging of the plaques. ST\/NCP\u2010PEG nanoparticles show efficacy in slowing the progression of atherosclerosis in live models and allow for simultaneous in vivo monitoring without observed toxicity in major organs. This positions ST\/NCP\u2010PEG nanoparticles as a promising strategy for the spontaneous diagnosis and treatment of atherosclerosis.\n                  <\/jats:p>","DOI":"10.1002\/smll.202401659","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T08:02:59Z","timestamp":1724659379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dual\u2010Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2360-4739","authenticated-orcid":false,"given":"Yuanzhe","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Department of Biomedical Engineering National University of Singapore  4 Engineering Drive 3, Block E4, #04\u201008 Singapore 117583 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Medical College Yangzhou University  Yangzhou Jiangsu 225001 China"},{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-4025","authenticated-orcid":false,"given":"Suet Yen","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"},{"name":"Cardiovascular Research Institute National University Heart Centre Singapore (NUHCS)  14 Medical Drive Singapore 117599 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Jun","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"},{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigao","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-7283","authenticated-orcid":false,"given":"Chenyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore  Singapore 117596 Singapore"},{"name":"Singapore Lipidomics Incubator (SLING) Life Sciences Institute National University of Singapore  Singapore 117456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Torta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore  Singapore 117596 Singapore"},{"name":"Singapore Lipidomics Incubator (SLING) Life Sciences Institute National University of Singapore  Singapore 117456 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry National University of Singapore  3 Science Drive 3 Singapore 117543 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering National University of Singapore  Singapore 117585 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-6929","authenticated-orcid":false,"given":"James Chen Yong","family":"Kah","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National University of Singapore  4 Engineering Drive 3, Block E4, #04\u201008 Singapore 117583 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-6082","authenticated-orcid":false,"given":"Jiong\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  1E Kent Ridge Rd Singapore 119228 Singapore"},{"name":"Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore  Singapore 117609 Singapore"},{"name":"Cardiovascular Research Institute National University Heart Centre Singapore (NUHCS)  14 Medical Drive Singapore 117599 Singapore"},{"name":"Department of Physiology Yong Loo Lin School of Medicine National University of Singapore  2 Medical Drive Singapore 117593 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.15836\/ccar.2013.424"},{"key":"e_1_2_9_2_1","volume-title":"Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging","author":"Athanasiou L. S.","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2010.02.006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.04.117"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/82219"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.1.115"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050461"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2437"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.06.020"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.03.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4065"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119963"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16439-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02037"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26284"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201702793"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00125"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c002073g"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.12.012"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic402194c"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803387"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R050252"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00018-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201703832"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp501030h"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b07535"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000339"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283307be8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000339"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283307be8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300084"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3520"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3578"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat1994.1.Supplemment1_S10"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.08.025"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.6.1909"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.05.035"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2001.tb00172.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2010.58"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00043-6"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01326"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00978.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00342-1"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-1-65"},{"key":"e_1_2_9_47_1","first-page":"001","volume":"3","author":"Kumar A.","year":"2011","journal-title":"Pharmacie Globale"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-005-5686-z"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12540"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2011.10.011"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.07.011"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1142\/9781860949074_0014"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-008-0678-5"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.06.035"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.12.042"},{"key":"e_1_2_9_56_1","volume":"7","author":"Venegas\u2010Pino D. E.","year":"2013","journal-title":"JoVE"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2013.03.001"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1400223"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7598-3_32"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab046"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0227-9"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2201443119"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b01385"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1063"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP279774"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568006043586134"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.7.993"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18444"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-8"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2710-2"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.10007"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2896"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062305"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c8fcd0"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030917"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202401659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202401659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202401659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:53:08Z","timestamp":1779281588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202401659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":75,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/smll.202401659"],"URL":"https:\/\/doi.org\/10.1002\/smll.202401659","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,26]]},"assertion":[{"value":"2024-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401659"}}