{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:07:31Z","timestamp":1793214451238,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 52002091"],"award-info":[{"award-number":["NSFC 52002091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20347"],"award-info":[{"award-number":["U22A20347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011204","name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials","doi-asserted-by":"publisher","award":["KF2305"],"award-info":[{"award-number":["KF2305"]}],"id":[{"id":"10.13039\/501100011204","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemodynamic therapy (CDT) is a non\u2010invasive strategy for generating reactive oxygen species (ROS) and is promising for cancer treatment. However, increasing ROS in tumor therapy remains challenging. Therefore, exogenous excitation and inhibition of electron\u2010hole pair recombination are attractive for modulating ROS storms in tumors. Herein, a Ce\u2010doped BiFeO<jats:sub>3<\/jats:sub> (CBFO) piezoelectric sonosensitizer to modulate ROS generation and realize a synergistic mechanism of CDT\/sonodynamic therapy and piezodynamic therapy (PzDT) is proposed. The mixed Fe<jats:sup>2+<\/jats:sup> and Ce<jats:sup>3+<\/jats:sup> can implement a circular Fenton\/Fenton\u2010like reaction in the tumor microenvironment. Abundant \u00b7OH can be generated by ultrasound (US) stimulation to enhance CDT efficacy. As a typical piezoelectric sonosensitizer, CBFO can produce O<jats:sub>2<\/jats:sub><jats:sup>\u2212<\/jats:sup> owing to the enhanced polarization by the US, resulting in the motion of charge carriers. In addition, CBFO can produce a piezoresponse irradiated upon US, which accelerates the migration rate of electrons\/holes in opposite directions and results in energy band bending, further achieving toxic ROS production and realizing PzDT. Density functional theory calculations confirmed that Ce doping shortens the diffusion of electrons and improves the conductivity and catalytic activity of CBFO. This distinct US\u2010enhanced strategy emphasizes the effects of doping engineering and piezoelectric\u2010optimized therapy and shows great potential for the treatment of malignant tumors.<\/jats:p>","DOI":"10.1002\/smll.202401931","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T09:26:30Z","timestamp":1714987590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Functional \u201cKey\u201d Amplified Piezoelectric Effect Modulates ROS Storm with an Open Source for Multimodal Synergistic Cancer Therapy"],"prefix":"10.1002","author":[{"given":"Chenghao","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Zang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-6594","authenticated-orcid":false,"given":"Lili","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshi","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education School of Chemistry and Materials Science Heilongjiang University  Harbin 150080 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzhi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Aerospace and Civil Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Modification of Chemical Fibers and Polymer Materials Donghua University  Shanghai 201620 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piaoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin 150001 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510031"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2020.124628"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218407"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202005865"},{"key":"e_1_2_7_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-021-00609-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006892"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120962"},{"key":"e_1_2_7_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202106106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203915"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303403"},{"key":"e_1_2_7_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210876"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208555"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202101278"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202302146"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002246"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134780"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c12942"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008540"},{"key":"e_1_2_7_8_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002439"},{"key":"e_1_2_7_8_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2015.03.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR03479D"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107054"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10228"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120278"},{"key":"e_1_2_7_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138782"},{"key":"e_1_2_7_11_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201912768"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.129458"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c16835"},{"key":"e_1_2_7_12_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104302"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11593"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101015"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c02361"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302579"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212259"},{"key":"e_1_2_7_14_3","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9461-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02674.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206594"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302579"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202300777"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.134017"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.021"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207687"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202209589"},{"key":"e_1_2_7_20_1","volume":"61","author":"Yang Z.","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0027606"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208256"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201907603"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201807279"},{"key":"e_1_2_7_23_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2018.01.033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03361"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2004.03.004"},{"key":"e_1_2_7_24_3","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111428"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106838"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300437"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04479-z"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00720G"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2022.122202"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202401931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T09:26:35Z","timestamp":1714987595000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202401931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":57,"alternative-id":["10.1002\/smll.202401931"],"URL":"https:\/\/doi.org\/10.1002\/smll.202401931","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2401931"}}