{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:36:25Z","timestamp":1790620585525,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21305097"],"award-info":[{"award-number":["21305097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Natural polyphenolic compound rosmarinic acid (RA) has good antitumor activity. However, the distinctive tumor microenvironment, characterized by low pH and elevated levels of glutathione (GSH), enhances the tolerance of tumors to the singular anti\u2010tumor treatment mode using RA, resulting in unsatisfactory therapeutic efficacy. Targeting nonapoptotic programmed cell death processes may provide another impetus to inhibit tumor growth. RA possesses the capability to coordinate with metal elements. To solve the effect restriction of the above single treatment mode, it is proposed to construct a self\u2010assembled nanocomposite, Fe\u2010RA. Under tumor microenvironment, Fe\u2010RA nanocomposite exerts the characteristics of POD\u2010like enzyme activity and depletion of GSH, producing a large amount of hydroxyl radical (\u00b7OH) while disrupting the antioxidant defense system of tumor cells. Moreover, due to the enhanced permeability and retention effect (EPR), Fe\u2010RA can transport Fe\n                    <jats:sup>2+<\/jats:sup>\n                    to a greater extent to tumor cells and increase intracellular iron content. Causing an imbalance in iron metabolism in tumor cells and promoting cell ferroptosis. The results of the synchrotron X\u2010ray absorption spectroscopy (XAS) and high\u2010resolution mass spectrometry (HRMS) prove the successful complexation of Fe\u2010RA nanocomposite. Density functional theory (DFT) explains the efficient catalytic mechanism of its peroxide\u2010like enzyme activity and the reaction principle with GSH.\n                  <\/jats:p>","DOI":"10.1002\/smll.202402073","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T06:05:49Z","timestamp":1714457149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Self\u2010Assembled Fe\u2010Phenolic Acid Network Synergizes with Ferroptosis to Enhance Tumor Nanotherapy"],"prefix":"10.1002","author":[{"given":"Yinyin","family":"Chen","sequence":"first","affiliation":[{"name":"College of Agronomy Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Agronomy Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Agronomy Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Agronomy Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Agronomy Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-2231","authenticated-orcid":false,"given":"Xianxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Science Sichuan Agricultural University  Chengdu Sichuan 611130 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706728"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.10.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01305-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103836"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139506"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-022-00859-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2020.100851"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.135966"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213828"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2023.116432"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216079"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106766"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.07.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03539-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04632"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300379"},{"key":"e_1_2_7_18_1","volume":"15","author":"Dos Santos A. 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