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Polydimethylsiloxane (PDMS) is commonly used in organ chip fabrication owing to its biocompatibility, flexibility, transparency, and ability to replicate features down to the nanoscale. However, the porous nature of PDMS leads to unintended absorption of small molecules, critically affecting the drug response analysis. Addressing this challenge, the precision drug testing organ chip (PreD chip) is introduced, an innovative platform engineered to minimize small molecule absorption while facilitating cell culture. This chip features a PDMS microchannel wall coated with a perfluoropolyether\u2010based lubricant, providing slipperiness and antifouling properties. It also incorporates an ECM\u2013coated semi\u2010porous membrane that supports robust multicellular cultures. The PreD chip demonstrates its outstanding antifouling properties and resistance to various biological fluids, small molecule drugs, and plasma proteins. In simulating the human gut barrier, the PreD chip demonstrates highly enhanced sensitivity in tests for dexamethasone toxicity and is highly effective in assessing drug transport across the human blood\u2013brain barrier. These findings emphasize the potential of the PreD chip in advancing organ chip\u2013based drug testing methodologies.<\/jats:p>","DOI":"10.1002\/smll.202402431","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:18:54Z","timestamp":1719476334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Lubricant\u2010Coated Organ\u2010on\u2010a\u2010Chip for Enhanced Precision in Preclinical Drug Testing"],"prefix":"10.1002","volume":"20","author":[{"given":"Tae Young","family":"Kim","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kijun","family":"Park","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SeungHwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Energy and Chemical Engineering Incheon National University (INU)  Incheon 22012 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong F.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Energy and Chemical Engineering Incheon National University (INU)  Incheon 22012 South Korea"},{"name":"Innovation Center for Chemical Engineering Incheon National University (INU)  Incheon 22012 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering College of Information and Biotechnology Ulsan National Institute of Science and Technology (UNIST)  Ulsan 44919 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8898-044X","authenticated-orcid":false,"given":"Jungmok","family":"Seo","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul 03722 Republic of Korea"},{"name":"Lynk Solutec lnc Yonsei University  50\u20131 Yonsei\u2010ro, Seodaemun\u2010gu Seoul 03722 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12577"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12980"},{"key":"e_1_2_9_3_1","first-page":"447","volume":"15","author":"Mullard A.","year":"2016","journal-title":"Nat. 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