{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:21:34Z","timestamp":1791501694950,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277055"],"award-info":[{"award-number":["22277055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177100"],"award-info":[{"award-number":["22177100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017330","name":"Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In pharmaceuticals, the structural and functional alterations induced by biotransformation are well\u2010documented. Many pharmaceuticals exist in various crystal forms, which govern their transformation and significantly impact their activity. However, in the field of inorganic nanomedicine, there is a paucity of research focusing on the influence of crystal form\u2010dependent \u201cmetabolism\u201d (transformation) on their activity and biomechanism. This study delves into the distinct performances of two crystal forms of manganese sulfide (MnS), namely \u03b1\u2010MnS and \u03b3\u2010MnS, in bacteria\u2010infected diabetic wound healing. In the initial stage of a wound, where the environment is neutral to slightly alkaline, MnS partially converts to Mn\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    O\n                    <jats:italic>\n                      <jats:sub>y<\/jats:sub>\n                    <\/jats:italic>\n                    (comprising Mn\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    and Mn\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    ) and concurrently produces hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S); the conversion efficiency of \u03b3\u2010MnS significantly surpasses that of \u03b1\u2010MnS. Additionally, \u03b3\u2010MnS is more soluble than \u03b1\u2010MnS, which allows it to generate more Mn\n                    <jats:sup>2+<\/jats:sup>\n                    . These components collectively contribute to the superior bacteriostatic properties of MnS. In wound related cells, MnS stimulates the production of collagen I and vascular endothelial growth factor (VEGF), promote the M1 macrophages polarizing to the M2 phenotype, for extracellular matrix (ECM) remodeling. Notably, different transformation products have distinct functions. Consequently, the activity of MnS is dependent on its original crystal form related solubility and transformation efficiency.\n                  <\/jats:p>","DOI":"10.1002\/smll.202402496","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:59:20Z","timestamp":1728953960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Crystal Form\u2010Dependent MnS for Diabetic Wound Healing: Performance and Mechanistic Insights"],"prefix":"10.1002","volume":"20","author":[{"given":"Xiaomeng","family":"Duan","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaikai","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Energy Science and Engineering Nanjing Tech University  Nanjing Jiangsu 210009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongchong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Yancheng Institute of Technology  Yancheng 224051 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-8623","authenticated-orcid":false,"given":"Shaohua","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-3782","authenticated-orcid":false,"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Bio\u2010functional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Nanjing Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1280"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules201018759"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06164-7"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.55705\/cmbr.2022.361677.1065"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202107807"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12613-022-2594-1"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215426"},{"key":"e_1_2_8_4_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27217-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113745"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203308"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.13372"},{"key":"e_1_2_8_6_1","volume":"40","author":"Senneville E.","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"e_1_2_8_6_2","author":"Schaper N. C.","year":"2023","journal-title":"Diabetes Metab. Res. Rev."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00864"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00631-w"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13374"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889811038970"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07835-1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c05170"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TA10553K"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2017.02.023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212655"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk8013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202370213"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713553"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713394"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00858-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202300151"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq1053"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.07.008"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920338117"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109634"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/am4004683"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202208364"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0173-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152287"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125636"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.07.006"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303297"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301879"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2019.01.185"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202402496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202402496","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202402496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:17:24Z","timestamp":1772993844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202402496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":42,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/smll.202402496"],"URL":"https:\/\/doi.org\/10.1002\/smll.202402496","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"2024-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2402496"}}