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The delivery of exogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S and in situ production of O\n                    <jats:sub>2<\/jats:sub>\n                    within atherosclerotic plaques can help suppress inflammatory cell infiltration and alleviate disease progression. However, the uncontrolled release of gas donors hinders achieving effective drug concentrations and causes toxic effects. Herein, diallyl trisulfide (DATS)\u2010loaded metal\u2010organic cage (MOC)\u201068\u2010doped MnO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles are developed as a microenvironment\u2010responsive nanodrug with the capacity for the in situ co\u2010delivery of H\n                    <jats:sub>2<\/jats:sub>\n                    S and O\n                    <jats:sub>2<\/jats:sub>\n                    to inflammatory cells within plaques. This nanomedicine exhibited excellent monodispersity and stability and protected DATS from degradation in the circulation. In vitro studies showed that the nanomedicine reduced macrophage polarization toward an inflammatory phenotype and inhibited the formation of foam cells, while suppressing the expression of NOD\u2010like receptor thermal protein domain associated protein 3 (NLRP3) and interleukin\u20101\u03b2. In a mouse model of ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    genotype, the nanomedicine reduces the plaque burden, inflammatory infiltration, and hypoxic conditions within the plaques. Furthermore, the treatment process and therapeutic effects can be monitored by magnetic resonance image (MRI), in real time upon Mn\n                    <jats:sup>2+<\/jats:sup>\n                    release from the acidic\u2010 and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010 microenvironment\u2010responsive MnO\n                    <jats:sub>2<\/jats:sub>\n                    nanoparticles. The DATS\u2010loaded MOC\u201068\u2010doped MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based nanodrug holds great promise as a novel theranostic platform for AS.\n                  <\/jats:p>","DOI":"10.1002\/smll.202402673","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T23:30:08Z","timestamp":1717716608000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Codelivery of Dual Gases with Metal\u2010Organic Supramolecular Cage\u2010Based Microenvironment\u2010Responsive Nanomedicine for Atherosclerosis Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Dongye","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiology Sun Yat\u2010Sen Memorial Hospital, Sun Yat\u2010Sen University  No. 107 Yanjiang Road West Guangzhou 510120 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