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Herein, a near\u2010infrared (NIR) light\u2010responsive hydrogel system is reported to achieve programmed tissue repair and regeneration through the synergetic effects of on\u2010demand drug delivery and mild heat stimulation. The spatiotemporal hydrogel system (HG\/MPa) composed of polydopamine\u2010coated Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:sub>x<\/jats:sub>\n                    MXene (MP) nanosheets decorated with acidic fibroblast growth factor (aFGF, a potent angiogenic drug) and hydroxypropyl chitosan\/gelatin (HG) hydrogel is developed to orchestrate the reconstruction of the osteo\u2010vascularization network and boost bone regeneration. Upon exposure to NIR light irradiation, the engineered HG\/MPa hydrogel can achieve the initial complete release of aFGF to induce rapid angiogenesis and provide sufficient blood supply, maximizing its biofunction in the defect area. This integrated hydrogel system demonstrated good therapeutic efficacy in promoting cell adhesion, proliferation, migration, angiogenesis, and osteogenic differentiation through periodic NIR irradiation. In vivo, animal experiments further revealed that the spatiotemporalized hydrogel platform synergized with mild photothermal treatment significantly accelerated critical\u2010sized bone defect healing by increasing the osteo\u2010vascularization network density, recruiting endogenous stem cells, and facilitating the production of osteogenesis\/angiogenesis\u2010related factors. Overall, smart\u2010responsive hydrogel could\u00a0enhance the reconstruction of the osteo\u2010vascularization network in bone regeneration.\n                  <\/jats:p>","DOI":"10.1002\/smll.202403003","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:03:01Z","timestamp":1728388981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Photoactivated Hydrogel Therapeutic System with MXene\u2010Based Nanoarchitectonics Potentiates Endogenous Bone Repair Through Reshaping the Osteo\u2010Vascularization Network"],"prefix":"10.1002","volume":"20","author":[{"given":"Minhao","family":"Wu","sequence":"first","affiliation":[{"name":"National Key laboratory of macromolecular drug development and manufacturing School of Pharmaceutical Science Wenzhou Medical University  Wenzhou 325035 China"},{"name":"Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan 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