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In this study, carbon dots with synergistic antibacterial and antioxidant properties, referred to as AA\u2010CDs, are developed specifically for diabetic wound healing using a straightforward solvothermal method. By utilizing cost\u2010effective precursors like citric acid and ascorbic acid, AA\u2010CDs are engineered to possess tailored functions of photothermal sterilization and ROS scavenging. The resulting AA\u2010CDs demonstrats broad\u2010spectrum antibacterial activity, particularly against multidrug\u2010resistant strains, along with efficient ROS scavenging both in solution and within cells. Additionally, AA\u2010CDs exhibits a protective effect against oxidative stress\u2010induced damage. Notably, with a high photothermal conversion efficiency (41.18%), AA\u2010CDs displays heat\u2010enhanced antioxidant performance, providing not only augmented ROS scavenging but also additional protection against oxidative stress, yielding a true \u201c1 + 1 &gt; 2\u201d effect. To facilitate their use in vivo, AA\u2010CDs are incorporated into a thermally responsive hydrogel, which exhibits evident anti\u2010inflammatory properties by modulating inflammatory factors and significantly promots the healing of diabetic wounds. This study underscores the value of integrated platforms for diabetic wound healing and highlights the potential of versatile CDs as promising therapeutic agents in biomedical applications.<\/jats:p>","DOI":"10.1002\/smll.202403160","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T07:00:00Z","timestamp":1721890800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Carbon Dots with Integrated Photothermal Antibacterial and Heat\u2010Enhanced Antioxidant Properties for Diabetic Wound Healing"],"prefix":"10.1002","volume":"20","author":[{"given":"Henggang","family":"Wang","sequence":"first","affiliation":[{"name":"International Joint Research Center for Photo\u2010responsive Molecules and Materials School of Chemical and Material Engineering Jiangnan University  Wuxi Jiangsu 214122 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