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Photothermal therapy (PTT) serves as a treatment for thrombosis that provides noninvasive thrombus dissolution and fewer bleeding side effects.\u00a0However, the high temperatures generated by PTT can exacerbate vascular inflammation and promote thrombus recurrence. In this study, a photothermal hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) nanogenerator (PSA@ADT\u2010OH) is constructed using a perylene\u2010cored photothermal agent (PSA) coassembled with a H\n                    <jats:sub>2<\/jats:sub>\n                    S donor ADT\u2010OH. The system PSA@ADT\u2010OH demonstrates outstanding targeting and accumulation efficiency against blood flow shear forces. It also provides sustained H\n                    <jats:sub>2<\/jats:sub>\n                    S release at thrombus sites, contributing to antiplatelet aggregation, reactive oxygen species clearance, and vascular healing. This approach opens up new possibilities for advanced thrombus treatment.\n                  <\/jats:p>","DOI":"10.1002\/smll.202403284","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:59:35Z","timestamp":1721642375000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["\u201cOne\u2010Stone\u2010Three\u2010Birds\u201d H\n                    <sub>2<\/sub>\n                    S\u2010Photothermal Therapy for Enhanced Thrombolysis and Vascular Healing"],"prefix":"10.1002","volume":"20","author":[{"given":"Xian","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key 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