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Here, \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>@TA@ALN magnetic nanoparticles (\u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>@TA@ALN MNPs) composed of \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>, tannic acid (TA), and alendronate sodium (ALN) are engineered to reconstruct the osteoarthritic microenvironment and mitigate TMJOA progression. \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>@TA@ALN MNPs can promote chondrocytes\u2019 proliferation, facilitate chondrogenesis and anisotropic organization, enhance lubrication and reduce cartilage wear, and encourage cell movement. Magnetic\u2010responsive \u03b3\u2010Fe<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>@TA@ALN MNPs also exhibit pH sensitivity, which undergoes decomposition within acidic environment to release ALN on demand. 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