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Inspired by the appearance that a gate can block the outside world and the characteristics of the sol\u2013gel transition can form a \u201cgate\u201d in the nasal cavity, a Drop to Gate nasal drop (DGND) is designed to set a gate in nose, which achieves protecting role from the influence of nasal environment. The DGND demonstrates the efficiency and application prospect of delivering drugs to the brain through the N\u2010to\u2010B. The effective concentration of single administration is increased through the hydrophobic interaction between C<jats:sub>8<\/jats:sub>\u2010GelMA and SRT1720 (SA), and then cross\u2010linked under UV to form nanogel, which can respond to MMP in the inflammatory microenvironment of sepsis\u2010induced cognitive dysfunction. Finally, the SA\/nanogel is compounded into the thermogel, which can respond to the nasal cavity temperature to form DGND in situ, increasing the residence time and delivery efficiency of drugs in the nasal cavity. 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