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In vitro tests confirmed that <jats:bold>FSSIO<\/jats:bold> possessed favorable biocompatibility and a pronounced ability to penetrate blood brain barrier. The FA moiety endowed the particles with remarkable antioxidant and anti\u2010inflammatory properties, and effectively protected neuron cells from the toxicity induced by A\u03b2. Moreover, the Simvastatin pharmacophore assists the particles up\u2010regulate the expression level of BDNF and significantly promotes the expression levels of p\u2010TrkB, p\u2010ERK, p\u2010PI3K and Akt, which consequently leads to the neurite outgrowth via regulating PI3K\/ATK and TrkB\u2010mediated signaling pathway. More importantly, in the Morris water maze test, <jats:bold>FSSIO<\/jats:bold> shows excellent activity to enhance the learning and memory retention of AD model rats.<\/jats:p>","DOI":"10.1002\/smll.202403625","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:45:45Z","timestamp":1725612345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["An Approach to Apply BDNF Targeting Fe<sub>3<\/sub>O<sub>4<\/sub>\u2010Based Nanoparticles as Multifunctional Anti\u2010Alzheimer Agents"],"prefix":"10.1002","volume":"20","author":[{"given":"Lei","family":"Fang","sequence":"first","affiliation":[{"name":"Jiangsu Province Hi\u2010Tech Key Laboratory for Biomedical Research and Pharmaceutical Research Center School of Chemistry and Chemical Engineering Southeast University  Nanjing 211189 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