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Current physical barriers either have a short residence time at the surgical site with a low tissue attachment capacity or are prone to undesired adhesion formation owing to the double\u2010sided adhesive property, which limits the POA prevention efficacy of the barriers. In this study, Janus\u2010structured microgels (Janus\u2010MGs) with asymmetric tissue adhesion capabilities are fabricated using a novel bio\u2010friendly gas\u2010shearing microfluidic platform. The anti\u2010adhesive side of Janus\u2010MGs, which consists of alginate, hyaluronic acid, and derivatives, endows the material with separation, lubrication, and adhesion prevention properties. The adhesive side provided Janus\u2010MGs with tissue attachment and retention capability through catechol\u2010based adhesion, thereby enhancing the in situ adhesion prevention effect. In addition, Janus\u2010MGs significantly reduced blood loss and shortened the hemostatic time in rats, further reducing adhesion formation. Three commonly used rat POA models with different tissue structures and motion patterns are established in this study, namely peritoneal adhesion, intrauterine adhesion, and peritendinous adhesion models, and the results showed that Janus\u2010MGs effectively prevented the occurrence of POA in all the models. The fabrication of Janus\u2010MGs offers a reliable strategy and a promising paradigm for preventing POA following diverse surgical procedures.<\/jats:p>","DOI":"10.1002\/smll.202403753","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T09:36:36Z","timestamp":1727516196000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Janus\u2010Structured Microgel Barrier with Tissue Adhesive and Hemostatic Characteristics for Efficient Prevention of Postoperative Adhesion"],"prefix":"10.1002","volume":"20","author":[{"given":"Zichuan","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Liang","sequence":"additional","affiliation":[{"name":"West China School of Nursing Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongrui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Orthopaedic Research Institute West China Hospital Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingli","family":"Li","sequence":"additional","affiliation":[{"name":"West China School of Nursing Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosheng","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target &amp; 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