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In this study, a bottlebrush polymer\u2010antisense oligonucleotide (ASO) conjugate, termed pacDNA, designed to target IL\u201017 receptor A (IL\u201017RA), which is involved in psoriasis pathogenesis is presented. Systemic administration of pacDNA led to its accumulation in epidermis, dermis, and hypodermis of mouse skin, reduced IL\u201017RA gene expression in skin, and significantly reversed the development of imiquimod (IMQ)\u2010induced psoriasis in a mouse model. 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