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To maximize treatment effectiveness, almost all oral medications utilize drug carriers, such as capsules, liposomes, and sugar coatings. However, these carriers rely on dissolution or fragmentation to achieve drug release, which leads to drugs and carriers coabsorption in the body, causing unnecessary adverse drug reactions, such as nausea, vomiting, abdominal pain, and even death caused by allergy. Therefore, the ideal oral drug carrier should avoid degradation and absorption and be totally excreted after drug release at the desired location. Herein, a gastrointestinally stable oral drug carrier based on porous aromatic framework\u20101 (PAF\u20101) is constructed, and it is modified with famotidine (a well\u2010known gastric drug) and mesalazine (a well\u2010known ulcerative colitis drug) to verify the excellent potential of PAF\u20101. The results demonstrate that PAF\u20101 can accurately release famotidine in stomach, mesalazine in the intestine, and finally be completely excreted from the body without any residue after 12 h. The use of PAF materials for the construction of oral drug carriers with no residue in the gastrointestinal tract provides a new approach for efficient disease treatment.<\/jats:p>","DOI":"10.1002\/smll.202404643","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T06:17:33Z","timestamp":1721197053000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Residue\u2010Free Orally Administered Drug Carrier Based on a Porous Aromatic Framework for Efficient Multisite Treatment"],"prefix":"10.1002","volume":"20","author":[{"given":"Enpeng","family":"Xi","sequence":"first","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education and Faculty of Chemistry Northeast Normal University  Changchun 130024 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Normal University  Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education and Faculty of Chemistry Northeast Normal University  Changchun 130024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangshan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education and Faculty of Chemistry Northeast Normal University  Changchun 130024 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