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Herein, the well\u2010known broad\u2010spectrum anticancer drug Ge\u2010132 which contains Ge<jats:sup>IV<\/jats:sup> as potential heteroatoms and carboxyl coordination sites, is introduced to the POM system, leading to the first organogermanium functionalized Ge<jats:sup>IV<\/jats:sup>\u2212Sb<jats:sup>III<\/jats:sup>\u2010templating POM nanocluster Na<jats:sub>4<\/jats:sub>[H<jats:sub>2<\/jats:sub>N(CH<jats:sub>3<\/jats:sub>)<jats:sub>2<\/jats:sub>]<jats:sub>16<\/jats:sub> H<jats:sub>18<\/jats:sub>[Sm<jats:sub>4<\/jats:sub>(H<jats:sub>2<\/jats:sub>O)<jats:sub>12<\/jats:sub>W<jats:sub>4<\/jats:sub>O<jats:sub>14<\/jats:sub>Ge(CH<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub>COOH)]<jats:sub>2<\/jats:sub>[SbW<jats:sub>9<\/jats:sub>O<jats:sub>33<\/jats:sub>]<jats:sub>4<\/jats:sub>[Ge(CH<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub>COOH) SbW<jats:sub>15<\/jats:sub>O<jats:sub>54<\/jats:sub>]<jats:sub>2<\/jats:sub>\u00b762H<jats:sub>2<\/jats:sub>O (<jats:bold>1<\/jats:bold>). An unprecedented organogermanium templating Dawson\u2010like [Ge(CH<jats:sub>2<\/jats:sub>CH<jats:sub>2<\/jats:sub>COOH)SbW<jats:sub>15<\/jats:sub>O<jats:sub>54<\/jats:sub>]<jats:sup>12\u2212<\/jats:sup> building block is discovered. To take advantage of the potential pharmaceutical activity of such an organogermanium\u2010functionalized POM cluster, <jats:bold>1<\/jats:bold> is further composited with gold nanoparticles (NPs) to prepare <jats:bold>1<\/jats:bold>\u2212Au NPs, which doubles the blood circulation time of <jats:bold>1<\/jats:bold>\u2010based nanodrug. Efficient separation of photogenerated charges in <jats:bold>1<\/jats:bold>\u2212Au NPs largely boosts the photothermal conversion efficiency (PCE\u00a0=\u00a055.0%), which is nearly 2.1 times that of either single <jats:bold>1<\/jats:bold> (PCE\u00a0=\u00a026.7%) or Au NPs (PCE\u00a0=\u00a026.2%), and simultaneously facilitate the generation of toxic activate reactive oxygen species in tumor microenvironment. Based on these findings, it is demonstrated that <jats:bold>1<\/jats:bold>\u2212Au NPs are a multifunctional and renal clearable nanomedicine with great potential in photoacoustic imaging guiding photothermal\u2013chemodynamic therapy for breast cancer.<\/jats:p>","DOI":"10.1002\/smll.202405068","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T10:51:36Z","timestamp":1722336696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Unprecedented Organogermanium Functionalized Ge<sup>IV<\/sup>\u2212Sb<sup>III<\/sup>\u2010Templating Polyoxotungstate Nanocluster for Photothermal\u2013Chemodynamic Cancer Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 China"},{"name":"Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Tang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Song","sequence":"additional","affiliation":[{"name":"Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin School of Pharmacy Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0665-2937","authenticated-orcid":false,"given":"Junwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Molecular Sciences Henan University  Kaifeng 475004 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.54"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2CS00582D"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01234-w"},{"key":"e_1_2_8_1_4","doi-asserted-by":"publisher","DOI":"10.26599\/POM.2023.9140048"},{"key":"e_1_2_8_1_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215058"},{"key":"e_1_2_8_1_6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094982"},{"key":"e_1_2_8_1_7","doi-asserted-by":"publisher","DOI":"10.26599\/POM.2023.9140051"},{"key":"e_1_2_8_1_8","volume":"2020","author":"Wang J.","year":"2020","journal-title":"Research."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201803868"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.214143"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214734"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004500"},{"key":"e_1_2_8_2_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.12.057"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08894"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03375"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202107265"},{"key":"e_1_2_8_3_4","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115336"},{"key":"e_1_2_8_3_5","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC09944A"},{"key":"e_1_2_8_3_6","first-page":"12","volume":"17","author":"S.\u2010Coelho A. 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