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For the first time, a two\u2010step controlled hydrothermal pyrolysis is reported to nanotize dopamine, phloroglucinol, and glutaraldehyde into carbon dot (CD) to be subsequently converted into carbonized polymer dot (CPD) with gelatin as a co\u2010substrate. Chemical crosslinking of CD with gelatin through Schiff base formation before the second pyrolysis step ensures a complex yet porous polymeric network. The retention of chemical functionalities indigenous to CD substrates and gelatin along with the preservation of CD photoluminescence in CPD for optical tracking is achieved. A unique nanoformulation is created with the CPD through tannic acid (TA) grafting evolving CPD\u2010TA nanoglue demonstrating \u22481.32\u00a0MPa strength in lap shear tests conducted on porcine skin, surpassing traditional bioadhesives. CPD\u2010TA nanoglue uploaded insulin as chosen cargo disbursal at the wound site for healing normal and in vitro diabetic wound models using HEKa cells with extraordinary biocompatibility. Most importantly, CPD\u2010TA can generate reactive oxygen species (ROS) and scavenge simultaneously under ambient conditions (23\u00a0W white LED or dark) for on\u2010demand sterilization or aiding wound recovery through ROS scavenging.<\/jats:p>","DOI":"10.1002\/smll.202405531","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:08:15Z","timestamp":1723766895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Carbonized Polymer Dot\u2010Tannic Acid Nanoglue: Tissue Reinforcement with Concurrent Fluorescent Tracking, Insulin Delivery, and Reactive Oxygen Species Regulation for Normal and Diabetic Wound Healing"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5848-3707","authenticated-orcid":false,"given":"Maansi","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Patna  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