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Anti\u2010tumor immunotherapy has now emerged as an important treatment for cancer. However, immunosuppressive tumor microenvironment limits the antitumor immunity. The importance of the immune system in the cancer treatment process must be emphasized. Herein, two precision\u2010targeted nanoparticles PD\u2010L1@Cur\u2010NPs and PD\u20101@AS\u2010NPs are constructed for cancer treatment. PD\u2010L1@Cur\u2010NPs can precisely target tumor cells in vivo to eradicate tumor cells or induce them apoptosis. PD\u20101@AS\u2010NPs can precisely target T cells in vivo to activate the T cell\u2010mediated immune system and induce antitumor immune responses. Furthermore, these two nanoparticles have good synergistic effect and show stronger antitumor effect after combination. After treatment with the combination of two nanoparticles, the tumor volumes of C57BL\/6 tumor\u2010bearing mice are significantly reduced. Moreover, the percentage of CD8<jats:sup>+<\/jats:sup>T cells and CD4<jats:sup>+<\/jats:sup>T cells in the tumor significantly increased, and the percentage of regulatory T cells significantly decreased. The percentage of memory T cells and memory effector T cells in the spleen also significantly increased after treatment, suggesting that the antitumor immunity is activated after treatment. This study provides a new antitumor treatment strategy combining chemotherapy and immunotherapy, which has good application prospect.<\/jats:p>","DOI":"10.1002\/smll.202405752","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:01:19Z","timestamp":1731661279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Combination Nanodrug Delivery Systems Facilitate the Syncretism of Chemotherapy with Immunotherapy to Promote Cancer Treatment"],"prefix":"10.1002","volume":"21","author":[{"given":"Zishuo","family":"Guo","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing 102488 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9858-4451","authenticated-orcid":false,"given":"Haocheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing 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