{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:05:27Z","timestamp":1789826727134,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"50","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672962"],"award-info":[{"award-number":["81672962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21905138"],"award-info":[{"award-number":["21905138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glioblastoma (GBM) recurrence leads to high mortality, which remains a major concern in clinical therapy. Herein, an injectable triptolide (TP)\u2010preloaded hydrogel (TP@DNH) accompanied by a postoperative injection strategy is developed to prevent the recurrence of GBM. With a potential inhibitor of the NRF2\/SLC7A11\/GPX4 axis, it is demonstrated that TP can deactivate glutathione peroxidase 4 (GPX4) from the source of glutathione (GSH) biosynthesis, thereby activating ferroptosis in GBM cells by blocking the neutralization of intracellular lipid peroxide (LPO). Based on acid\u2010sensitive Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/tannic acid (TA) metal\u2010phenolic networks (MPNs), the TP@DNH hydrogel can induce the effective generation of reactive oxygen species (ROS) through Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/TA\u2010mediated Fenton reaction and achieve controllable release of TP in resected GBM cavity. Due to ROS generation and GPX4 deactivation, postoperative injection of TP@DNH can achieve high\u2010level ferroptosis through dual\u2010pathway LPO accumulation, remarkably suppressing the growth of recurrent GBM and prolonging the overall survival in orthotopic GBM relapse mouse model. This work provides an alternative paradigm for regulating ferroptosis in the postoperative treatment of GBM.\n                  <\/jats:p>","DOI":"10.1002\/smll.202406036","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T02:05:45Z","timestamp":1728353145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Postoperative Injection of a Triptolide\u2010Preloaded Hydrogel Prevents the Recurrence of Glioblastoma by Dual\u2010Pathway Activation of Ferroptosis"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-8734","authenticated-orcid":false,"given":"Hongshuai","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cell Biology School of Basic Medical Sciences Nanjing Medical University  Nanjing 211166 P. R. 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