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The zinc oxide\/copper sulfide (ZnO\u2010CuS) microspheres (MSs) developed in this work can kill bacteria and resist inflammation. ZnO\u2010CuS exhibits different enzyme\u2010like activities depending on pH. In acidic environments, ZnO\u2010CuS exhibits peroxidase\u2010like (POD\u2010like) activity and can convert hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) into hydroxyl radicals (\u2022OH) for sterilization. Under neutral conditions, ZnO\u2010CuS removes reactive oxygen species (ROS) and can convert excess ROS into water and oxygen. The in vitro results of the antibacterial test demonstrate the pronounced disruption effect of ZnO\u2010CuS on the bacterial biofilm and cell membrane. The transcriptome sequencing results of wounded animal tissue reveal that ZnO\u2010CuS MSs increase the expression of proteins produced by immune cells, and reduce the expression levels of inflammatory factors at the wound site. Therefore, antimicrobial activity and rapid wound healing can be achieved by regulating the immune response and reducing the inflammatory response. The results from hemolysis, routine blood and blood biochemistry analyses demonstrate the excellent biosecurity of the ZnO\u2010CuS MSs.\n                  <\/jats:p>","DOI":"10.1002\/smll.202406356","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T09:31:19Z","timestamp":1731144679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Zinc Oxide\u2010Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses"],"prefix":"10.1002","volume":"21","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"College and Hospital of Stomatology Anhui Medical University Key Lab. of Oral Diseases Research of Anhui Province  Hefei 230032 China"},{"name":"School of Biomedical Engineering Research and Engineering Center of Biomedical Materials Anhui Provincial Institute of Translational Medicine Anhui 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