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To address this issue, a microneedle (MN) system loaded with copper\u2010manganese oxide (CMO) is developed to modulate the hyperimmune response in wounds. CMO@MN exhibits excellent antimicrobial and anti\u2010inflammatory properties by effectively killing bacteria, scavenging ROS, and modulating macrophage polarization through their multiple enzymatic activities and photothermal properties. RNA sequencing revealed that CMO@MN improved the therapeutic effect on the infected skin of mice by balancing the ratio of M1\/M2 macrophages and promoting cell migration and angiogenesis through the regulation of relevant pathways. Overall, this CMO@MN patch skillfully balances the complex issues between the immune response and wound healing and has potential applications in the treatment of other serious bacterial infections.<\/jats:p>","DOI":"10.1002\/smll.202406377","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:11:23Z","timestamp":1728259883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Local Release of Copper Manganese Oxide Using HA Microneedle for Improving the Efficacy of Drug\u2010Resistant Wound Inflammation"],"prefix":"10.1002","volume":"20","author":[{"given":"Cheng","family":"Gu","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Anhui Provincial Institute of Translational Medicine Anhui Medical University  Hefei 230032 P. R. China"},{"name":"Anhui Engineering Research Center for Medical Micro\u2010Nano Devices  Hefei Anhui 230012 P. R. 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