{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:27:30Z","timestamp":1787315250128,"version":"build-2736575974"},"reference-count":83,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Triple\u2010negative breast cancer (TNBC) presents a formidable challenge due to its aggressive behavior and\u00a0limited array of treatment options available. This study focuses on employing nanoaggregate material of organometallic Ir(III) complexes for treating\u00a0TNBC cell line MDA\u2010MB\u2010231. In this approach, Ir(III) complexes with enhanced cellular permeability are strategically designed and achieved through the incorporation of COOMe groups into their structure. The lead compound, IrL\n                    <jats:sup>1<\/jats:sup>\n                    , exhibits promiscuous nanoscale aggregation in RPMI cell culture media, characterized by a stable hydrodynamic effective diameter ranging from 190 to 202 nm over 48 h.\u00a0With excellent photo\u2010responsive contrast\u2010enhanced cell imaging properties IrL\n                    <jats:sup>1<\/jats:sup>\n                    exhibits an outstanding IC\n                    <jats:sub>50, 48h<\/jats:sub>\n                    \u00a0value of 36.05\u00b1 0.03 n\n                    <jats:sc>m<\/jats:sc>\n                    when irradiated with 390 nm light in MDA\u2010MB\u2010231 (IC\n                    <jats:sub>50, 48 h<\/jats:sub>\n                    \u00a0of Cisplatin is 5.29 \u00b5\n                    <jats:sc>\u00b5<\/jats:sc>\n                    ).\u00a0In cell, investigation confirms that IrL\n                    <jats:sup>1<\/jats:sup>\n                    nanoaggregates internalization via energy\u2010dependent endocytosis\u00a0undergo ferroptosis and ROS mediated cell death in MDA\u2010MB\u2010231 cells.\u00a0Further, these in vivo studies using NOD\u2010SCID\u00a0mice confirmed that IrL\n                    <jats:sup>1<\/jats:sup>\n                    \u00a0exhibits a tendency to ablate tumors inoculated in mice models at therapeutically relevant doses.\u00a0Thus, this comprehensive approach holds promise for expanding the repertoire of organometallic Ir(III) nanoaggregates with adaptable characteristics, thereby advancing their clinical utility of nanomedicine in the holistic treatment of metastatic 3D\u00a0triple\u2010negative breast tumor spheroids.\n                  <\/jats:p>","DOI":"10.1002\/smll.202406809","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:05:08Z","timestamp":1732788308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Endocytic Uptake of Self\u2010Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple\u2010Negative Breast Tumor Spheroids"],"prefix":"10.1002","volume":"21","author":[{"given":"Ayushi","family":"Chaudhary","sequence":"first","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshu","family":"Sonker","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayari","family":"Dewan","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutwik Anil","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5826-0719","authenticated-orcid":false,"given":"Ritika Gautam","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry IIT Kanpur  Kanpur UP 208016 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"1481","volume":"27","author":"Choi J.","year":"2012","journal-title":"Histol. Histopathol."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01180"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174280"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt303"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.66"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0625"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.e12501"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08664"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202100438"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111599"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QI00920A"},{"key":"e_1_2_9_15_1","volume":"9","author":"Chen M. H.","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05302"},{"key":"e_1_2_9_17_1","volume":"53","author":"He L.","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00242D"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014959"},{"key":"e_1_2_9_20_1","volume":"12","author":"Mondal A.","year":"2022","journal-title":"RSC Adv."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00586"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb800065s"},{"key":"e_1_2_9_21_3","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161020-00011"},{"key":"e_1_2_9_21_4","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631030-00002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC02901A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c13137"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38954"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246122"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201471"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic2014013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05302"},{"key":"e_1_2_9_29_1","volume":"64","author":"Singh N.","year":"2021","journal-title":"J. Med. Chem."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-023-01199-w"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4746"},{"key":"e_1_2_9_31_2","volume":"142","author":"Zhou X. Q.","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_9_31_3","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S467354"},{"key":"e_1_2_9_31_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2016.03.004"},{"key":"e_1_2_9_31_5","doi-asserted-by":"publisher","DOI":"10.1115\/1.4037392"},{"key":"e_1_2_9_31_6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.12.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06171F"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC03096B"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(00)19056-1"},{"key":"e_1_2_9_36_1","volume":"142","author":"Sen S.","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3440"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200604016"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00259C"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.004"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00011"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524016666160829152658"},{"key":"e_1_2_9_43_1","volume":"61","author":"Kuznetcova I.","year":"2022","journal-title":"Inorg. Chem."},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385114-7.00004-0"},{"key":"e_1_2_9_43_3","volume":"99","author":"Yan W.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/35014014"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013987"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01704"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja411006a"},{"key":"e_1_2_9_46_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01249-3"},{"key":"e_1_2_9_46_4","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.8b00199"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202306179"},{"key":"e_1_2_9_47_2","doi-asserted-by":"crossref","unstructured":"b)J.Cao Y.Zheng X.Wu C. P.Tan M. H.Chen N.Wu L. N.Ji Z. W.Mao 2019 62 3311.","DOI":"10.1021\/acs.jmedchem.8b01704"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-022-03033-x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QI01653F"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.10"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26845"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.226"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.06.017"},{"key":"e_1_2_9_52_3","first-page":"8174","volume":"60","author":"Hao Y.","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_9_52_4","first-page":"62","volume":"2023","author":"Lv M.","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_9_52_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116295"},{"key":"e_1_2_9_52_6","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC06171F"},{"key":"e_1_2_9_52_7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115247"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-013-1032-2"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.136.B864"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.140.A1133"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1103\/RevModPhys.71.1253"},{"key":"e_1_2_9_57_1","unstructured":"M. J.Frisch G. W.Trucks H. B.Schlegel G. E.Scuseria M. A.Robb J. R.Cheeseman G.Scalmani V.Barone G. A.Petersson H.Nakatsuji X.Li M.Caricato A. V.Marenich J.Bloino B. G.Janesko R.Gomperts B.Mennucci H. P.Hratchian J. V.Ortiz A. F.Izmaylov J. L.Sonnenberg D.Williams\u2010Young F.Ding F.Lipparini F.Egidi J.Goings B.Peng A.Petrone T.Henderson D.Ranasinghe et\u00a0al. Fox D. J. G. Inc W. C. Gausian16 2016."},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.448975"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.448800"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306328"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.448799"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201906605"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2179"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202406809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202406809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202406809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:04:15Z","timestamp":1773011055000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202406809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":83,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/smll.202406809"],"URL":"https:\/\/doi.org\/10.1002\/smll.202406809","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2406809"}}