{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:33:53Z","timestamp":1790771633402,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"51","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072546"],"award-info":[{"award-number":["82072546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272434"],"award-info":[{"award-number":["82272434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bacterial biofilm formation is closely associated with persistent infections of medical implants, which can lead to implantation failure. Additionally, the reconstruction of the vascular network is crucial for achieving efficient osseointegration. Herein, an anti\u2010biofilm nanoplatform based on L\u2010arginine (LA)\/new indocyanine green (NICG) that is anchored to strontim titanium oxide (SrTiO\n                    <jats:sub>3<\/jats:sub>\n                    ) nano\u2010arrays on a titanium (Ti) substrate by introducing polydopamine (PDA) serving as the interlayer is designed and successfully fabricated. Near\u2010infrared light (NIR) is used to excite NICG, generating reactive oxygen species (ROS) that react with LA to release nitric oxide (NO) molecules. Utilizing the concentration\u2010dependent effect of NO, high power density NIR irradiation applied during the early stage after implantation to release a high concentration of NO, which synergized with the photothermal effect of PDA to eliminate bacterial biofilm. Subsequently, the irradiation power density can be finely down\u2010regulated to reduce the NO concentration in subsequent treatment for accelerating the reconstruction of blood vessels. Meanwhile, SrTiO\n                    <jats:sub>3<\/jats:sub>\n                    nano\u2010arrays improve the hydrophilicity of the implant surface and slowly release strontium (Sr) ions for continuously optimizing the osteogenic microenvironment. Effective biofilm elimination and revascularization alongside the continuous optimization of the osteogenic microenvironment can significantly enhance the osseointegration of the functionalized Ti implant in in vivo animal experiments.\n                  <\/jats:p>","DOI":"10.1002\/smll.202407078","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T01:00:02Z","timestamp":1727744402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Amino Acid Functionalized SrTiO\n                    <sub>3<\/sub>\n                    Nanoarrays with Enhanced Osseointegration Through Programmed Rapid Biofilm Elimination and Angiogenesis Controlled by NIR\u2010Driven Gas Therapy"],"prefix":"10.1002","volume":"20","author":[{"given":"Zheng","family":"Liu","sequence":"first","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehan","family":"Wang","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilun","family":"Xu","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Liu","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Analytical &amp; Testing Center, Department of Orthopedics Surgery and Orthopedic Research Institute, West China Hospital Sichuan University  Chengdu 610065 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-5092","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Analytical &amp; 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