{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:30:07Z","timestamp":1793791807446,"version":"4.6.1"},"reference-count":38,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030258"],"award-info":[{"award-number":["2024A1515030258"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Accurate determination of cerebral ascorbic acid (AA) is crucial for understanding ischemic stroke (IS) related pathological events. Carbon fiber microelectrodes (CFEs) have proven to be robust tools with high sensitivity toward AA, however, they face ongoing challenges for in situ measurement due to the non\u2010specific adsorption of proteins in brain tissue. In this study, the hydrogen\u2010bonded organic framework PFC\u201071 is synthesized and modified on CFEs through \u03c0\u2010\u03c0 stacking interactions with carboxylated carbon nanotubes (CNT\n                    <jats:sub>\u2010COOH<\/jats:sub>\n                    ). It is found that the gating effect and hydrophilicity of PFC\u201071 provided the CFE with excellent antibiofouling properties. As a result, AA exhibited a low oxidation potential of \u221230\u00a0mV on the CFE\/CNT\n                    <jats:sub>\u2010COOH<\/jats:sub>\n                    \/PFC\u201071, even in the presence of 20\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    bovine serum albumin. Given the structural advantages of CFE\/CNT\n                    <jats:sub>\u2010COOH<\/jats:sub>\n                    \/PFC\u201071, a ratiometric electrochemical strategy for AA is established, enabling the in situ assay of cerebral AA in a middle cerebral artery occlusion (MCAO) model with high accuracy and stability.\n                  <\/jats:p>","DOI":"10.1002\/smll.202407101","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T15:29:23Z","timestamp":1728833363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hydrogen\u2010Bonded Organic Framework Enhanced Antifouling Property for Efficient In Situ Electrochemical Assay of Cerebral Ascorbic Acid"],"prefix":"10.1002","volume":"20","author":[{"given":"Zhiyuan","family":"Zheng","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory for Research and Evaluation of Drug Metabolism Guangdong Provincial Key Laboratory 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