{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:04:24Z","timestamp":1792587864020,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2603900"],"award-info":[{"award-number":["2022YFC2603900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22325801"],"award-info":[{"award-number":["22325801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A2085"],"award-info":[{"award-number":["U21A2085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020593","name":"Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology","doi-asserted-by":"publisher","award":["QNTD2023\u201001"],"award-info":[{"award-number":["QNTD2023\u201001"]}],"id":[{"id":"10.13039\/100020593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020593","name":"Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology","doi-asserted-by":"publisher","award":["buctrc201915"],"award-info":[{"award-number":["buctrc201915"]}],"id":[{"id":"10.13039\/100020593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the increasing spread of multidrug\u2010resistant (MDR) bacteria worldwide, it is needed to develop antibiotics\u2010alternative strategies for the treatment of bacterial infections. This work develops a multifunctional single\u2010component palladium nanosheet (PdNS) with broad\u2010spectrum and highly effective bactericidal activity against MDR bacteria. PdNS exerts its endogenous nanoknife (mechanical cutting) effect and peroxidase\u2010like activity independent of light. Under near\u2010infrared region (NIR) light irradiation, PdNS exhibits photothermal effect to produce local heat and meanwhile possesses photodynamic effect to generate <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub>; notably, PdNS has catalase\u2010like activity\u2010dependent extra photodynamic effect upon H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> addition. PdNS+H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>+NIR employs a collectively synergistic mechanism of nanoknife effect, peroxidase\/catalase\u2010like catalytic activity, photothermal effect, and photodynamic effect for bacterial killing. PdNS+H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>+NIR causes compensatory elevated phospholipid biosynthesis, disordered energy metabolism, increased cellular ROS levels and excessive oxidative stress, and inhibited nucleic acid synthesis in bacteria. In mice, PdNS+H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>+NIR gives &gt;92.7% bactericidal rates at infected wounds and almost the full recovery of infected wounds, and it leads to extensive down\u2010regulation of proinflammatory pathways and comprehensive up\u2010regulation of wound healing pathways, conferring elevated inflammation resolution and meanwhile accelerated wound repair. PdNS+H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>+NIR represents a highly efficient nanoplatform for photoenhanced treatment of superficial infections.<\/jats:p>","DOI":"10.1002\/smll.202407180","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T03:25:49Z","timestamp":1728876349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Advanced Palladium Nanosheet\u2010Enhanced Phototherapy for Treating Wound Infection Caused by Multidrug\u2010Resistant Bacteria"],"prefix":"10.1002","volume":"21","author":[{"given":"Shanshan","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolong","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nier","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"},{"name":"Northern Medical Branch of PLA General Hospital  Beijing 100094 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haokun","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-6091","authenticated-orcid":false,"given":"Zhijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-8501","authenticated-orcid":false,"given":"Huiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity Academy of Military Medical Sciences  Beijing 100071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3380"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00181-19"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10101310"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00313-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00539"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901872"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201904751"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2022.107994"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101638"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12598-021-01822-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmef.0021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105591"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.04.035"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2023.112231"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01371"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121084"},{"key":"e_1_2_8_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105252"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202609"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310920"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201602197"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202112145"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68231-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099209"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08643"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202208061"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00108"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.13.3890-3902.2001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.01.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom11050700"},{"key":"e_1_2_8_26_3","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202407180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T15:20:49Z","timestamp":1739373649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202407180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/smll.202407180"],"URL":"https:\/\/doi.org\/10.1002\/smll.202407180","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]},"assertion":[{"value":"2024-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2407180"}}