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A potential solution lies in combining gas therapy with targeted interventional ablation therapy. In this study, HA\u2010As\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles with controlled sizes are synthesized using different molecular weights of sodium hyaluronate (HA) as a supramolecular scaffold. Initially, HA co\u2010assembles with arsenic ions (As\n                    <jats:sup>3+<\/jats:sup>\n                    ) via coordinate bonds, forming HA\u2010As\n                    <jats:sup>3+<\/jats:sup>\n                    scaffold intermediates. These intermediates, varying in size, then react with sulfur ions to produce size\u2010controlled HA\u2010As\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    particles. This approach demonstrates that different molecular weights of HA enable precise control over the particle size of arsenic sulfide, offering a straightforward and environmentally friendly method for synthesizing metal sulfide particles. In an acidic environment, HA\u2010As\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>3<\/jats:sub>\n                    nanoparticles release hydrogen sulfide(H\n                    <jats:sub>2<\/jats:sub>\n                    S) gas and As\n                    <jats:sup>3+<\/jats:sup>\n                    . The released As\n                    <jats:sup>3+<\/jats:sup>\n                    directly damage tumor mitochondria, leading to substantial reactive oxygen species (ROS) production from mitochondria. Concurrently, the H\n                    <jats:sub>2<\/jats:sub>\n                    S gas inhibits the activity of catalase (CAT) and complex IV, preventing the beneficial decomposition of ROS and disrupting electron transfer in the mitochondrial respiratory chain. Consequently, it is found that H\n                    <jats:sub>2<\/jats:sub>\n                    S gas significantly enhances the mitochondrial damage induced by arsenic nanodrugs, effectively killing local tumors and ultimately eliminating cancer pain in mice.\n                  <\/jats:p>","DOI":"10.1002\/smll.202407197","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T01:32:13Z","timestamp":1727919133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synergistic Gas Therapy and Targeted Interventional Ablation With Size\u2010Controllable Arsenic Sulfide (As\n                    <sub>2<\/sub>\n                    S\n                    <sub>3<\/sub>\n                    ) Nanoparticles for Effective Elimination of Localized Cancer Pain"],"prefix":"10.1002","volume":"20","author":[{"given":"Yu","family":"Tang","sequence":"first","affiliation":[{"name":"Institute of 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