{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:29:55Z","timestamp":1790141395086,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173150"],"award-info":[{"award-number":["52173150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute organ injuries, such as acute kidney injury (AKI) and acute liver injury (ALI), usually present high morbidity and mortality in patients. However, the current clinical treatments remain limited, especially the lack of effective drug\u2010based treatment. Since these acute injuries are often associated with reactive oxygen species (ROS) overproduction, it is a promising strategy to develop therapeutic agents with potent ROS scavenging ability and excellent biocompatibility for efficient antioxidation therapy. Black phosphorus quantum dots (BPQDs), low\u2010dimensional nanomaterials prepared through a straightforward one\u2010step method and capable of complete controllable biodegradation, offer significant potential. This study comprehensively explores the extensive free\u2010radical scavenging capabilities of BPQDs, underscoring their immense potential in treating ROS\u2010related organ injuries. BPQDs could simultaneously achieve radical scavenging of DPPH, ABTS\u00b7, OH\u00b7, and O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u00b7 and exhibit excellent cytoprotective effects against ROS\u2010mediated damage even at extremely low dosages. Besides, the ultrasmall size of BPQDs (\u22483\u20105\u00a0nm) allows them to effectively penetrate the glomerular filtration barrier (\u22486\u00a0nm), significantly improving the symptoms of AKI and ALI in vivo. The therapeutic efficacy and great biocompatibility of BPQDs facilitate the clinical management of ROS\u2010related diseases, which will broaden the applications of QDs in the field of biomedicine.\n                  <\/jats:p>","DOI":"10.1002\/smll.202407543","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T04:40:27Z","timestamp":1731040827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ultrasmall Black Phosphorus Quantum Dots with Robust Antioxidative Properties for Acute Kidney and Liver Injury Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Jingyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology Guangzhou First People's Hospital School of Medicine South China University of Technology  Guangzhou 510180 China"},{"name":"Smart Manufacturing Thrust The Hong Kong University of Science and Technology (Guangzhou)  Guangzhou Guangdong 511400 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nephrology Center of Kidney and Urology The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen 518107 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou)  Nansha Guangzhou Guangdong 511400 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufan","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Bio\u2010Pharmaceutics Guangdong Pharmaceutics University  Guangzhou 510006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology General Hospital of Southern Theater Command of People's Liberation Army  Guangzhou 510010 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Guangzhou First People's Hospital School of Medicine South China University of Technology  Guangzhou 510180 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0678-3435","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology (Guangzhou)  Nansha Guangzhou Guangdong 511400 China"},{"name":"Division of Life Science The Hong Kong University of Science and Technology  Hong Kong SAR 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21714-2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00758-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00689-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-023-5547-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR01954C"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-020-3067-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02254-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01712-2"},{"key":"e_1_2_9_9_1","volume":"15","author":"Kim Y. 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