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Excess ROS not only hinders the osteogenic differentiation of bone marrow\u2010derived mesenchymal stem cells (BMSCs) but also impairs mitochondrial structure and function, resulting in irreversible cellular damage. Herein, a biomimetic multifunctional scaffold comprising Zn\u2010modified metal\u2013organic framework 818 (Zn\u2010MOF\u2010818) loaded with deferoxamine (DFO), gelatin methacryloyl (GelMA) hydrogel, and demineralized bone matrix (DBM) is shown to scavenge excess ROS, promote angiogenesis, and regulate immunity. Introduced Zn significantly enhances the superoxide dismutase\u2010 and catalase\u2010like activities of MOF\u2010818, which increases ROS\u2010scavenging efficiency. Zn\u2010MOF\u2010818 disrupts the vicious intracellular cycle of mitochondrial dysfunction and ROS accumulation by enhancing mitophagy, stabilizing mitochondrial function, and upregulating antioxidant genes. Additionally, Zn\u2010MOF\u2010818 facilitates the polarization of macrophages toward the M2 phenotype and alleviates inflammation, creating an advantageous immune microenvironment for osteogenic differentiation of BMSCs. The release of DFO, an activator of the HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    pathway, and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    from Zn\u2010MOF\u2010818, along with the secretion of various cytokines from DBM (such as bone morphogenetic proteins and vascular endothelial growth factors), enhances angiogenesis and osteogenesis. This scaffold targets multiple factors concurrently, offering a promising new approach for treating SONFH.\n                  <\/jats:p>","DOI":"10.1002\/smll.202407758","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:17:18Z","timestamp":1732249038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Multifunctional Scaffold Comprising Metal\u2013Organic Framework, Hydrogel, and Demineralized Bone Matrix for the Treatment of Steroid\u2010Induced Femoral Head Necrosis"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6299-3875","authenticated-orcid":false,"given":"Liangjie","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong 250021 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