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However, conventional tumor microenvironment\u2010responsive nanomedicines are often difficult to achieve both specificity and sensitivity, leading to severe adverse effects or limited drug release efficiency. Furthermore, the immunosuppressive microenvironment of tumor will also seriously restrict the treatment efficacy. In this work, a cascade\u2010responsive multi\u2010polyprodrug nanoregulator is developed. Under the tumor microenvironment with high hydrogen peroxide level, the nanoregulators can simultaneously release chemotherapeutic drugs (doxorubicin), indoleamine 2,3\u2010dioxygenase 1 inhibitor (1\u2010methyl\u2010tryptophan) and cinnamaldehyde in a self\u2010accelerating manner. The combination of reactive oxygen species\u2010induced ferroptosis and doxorubicin\u2010induced apoptosis can synergistically enhance immunogenic cell death and activate the immune response. The released1\u2010methyl\u2010tryptophan can promote cytotoxic T lymphocyte activation and reduce immune escape by inhibiting the tryptophan conversion. Meanwhile, it also enhances ferroptosis by inhibiting reactive oxygen species scavenging and cystine\/glutamate antiporter expression, achieving the positive feedback ferroptosis\u2010immunotherapy. 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