{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:10:20Z","timestamp":1791443420675,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012172","name":"Double First Class University Plan","doi-asserted-by":"publisher","award":["CPU2018GY25"],"award-info":[{"award-number":["CPU2018GY25"]}],"id":[{"id":"10.13039\/501100012172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells and disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability in the gut and lack of targeting, hindering precise intervention at the lesion site. This study prepares an L\u2010Arginine\u2010modified selenium nanozyme (Se\u2010CA) for the targeted oral treatment of UC. Se\u2010CA specifically targets M1\u2010type macrophages at sites of inflammation by binding to cationic amino acid transporter protein 2 on the surface of M1\u2010type macrophages. In vitro studies show that Se\u2010CA scavenges reactive ROS and reactive nitrogen species (RNS) in artificial gastric acid and intestinal fluids, and inhibits iron death in intestinal epithelial cells. In mice model of ulcerative colitis, oral administration of Se\u2010CA is effective in the treatment of colitis through its anti\u2010inflammatory and antioxidant properties, inhibition of iron death and regulation of intestinal flora. In conclusion, this work provides new insights into the targeted oral treatment of UC.<\/jats:p>","DOI":"10.1002\/smll.202408205","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T01:06:42Z","timestamp":1736212002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["L\u2010Arginine\u2010Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis"],"prefix":"10.1002","volume":"21","author":[{"given":"Shuaiwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chemistry Key Laboratory of Biomedical Functional Materials School of Science China Pharmaceutical University Nanjing 211198 P. R. 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