{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:28:25Z","timestamp":1791908905285,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012336","name":"Major State Basic Research Development Program of China","doi-asserted-by":"publisher","award":["2023YFB3810000"],"award-info":[{"award-number":["2023YFB3810000"]}],"id":[{"id":"10.13039\/501100012336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20333"],"award-info":[{"award-number":["U22A20333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925019"],"award-info":[{"award-number":["81925019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1705281"],"award-info":[{"award-number":["U1705281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302403"],"award-info":[{"award-number":["82302403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202330"],"award-info":[{"award-number":["82202330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720190088"],"award-info":[{"award-number":["20720190088"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720200019"],"award-info":[{"award-number":["20720200019"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023T160383"],"award-info":[{"award-number":["2023T160383"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220530143213029"],"award-info":[{"award-number":["JCYJ20220530143213029"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","award":["NCET\u201013\u20100502"],"award-info":[{"award-number":["NCET\u201013\u20100502"]}],"id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020Y4003"],"award-info":[{"award-number":["2020Y4003"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high\u2010throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real\u2010time visual guidance for in vivo endovascular embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity of the microrobots are identified. Therefore, the ML\u2010optimized iGHOST enables continuous production of uniform microrobots with programmable sizes (400\u22121000\u00a0\u00b5m) at an ultrahigh rate exceeding 240\u00a0mL\u00a0h<jats:sup>\u22121<\/jats:sup> by oscillatory segmenting fluid into droplets before ionic cross\u2010linking, and without requiring purification. Particularly, the iGHOST\u2010fabricated magnetically responsive lipiodol\u2010calcium alginate (MagLiCA) microrobots are highly distinguishable under X\u2010ray imaging, which allows for precise navigation in fluid flows of up to 4\u00a0mL\u00a0min<jats:sup>\u22121<\/jats:sup> and accurate embolization in liver and kidney blood vessels, thus addressing the current issues. Crucially, MagLiCA microrobots possess drug\u2010loading capabilities, enabling simultaneous embolization and site\u2010specific treatment. The iGHOST process is an intelligent, rapid, and green manufacturing method, which can produce size\u2010controllable, multifunctional microrobots with the potential for precise drug delivery and treatment under real\u2010time imaging across various medical applications.<\/jats:p>","DOI":"10.1002\/smll.202408613","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T07:17:07Z","timestamp":1734333427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intelligent Generic High\u2010Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real\u2010Time Visual Guidance During Embolization"],"prefix":"10.1002","volume":"21","author":[{"given":"Xuqi","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitian","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Gui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Naval Medical Center of PLA Naval Medical University  Shanghai 200052 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery Institute of Hepatobiliary\u2010Pancreatic\u2010Intestinal Diseases Affiliated Hospital of North Sichuan Medical College  Nanchong 637000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Vascular &amp; Tumor Interventional Radiology The First Affiliated Hospital of Xiamen University School of Medicine Xiamen University  Xiamen 361000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Artificial Intelligence Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Artificial Intelligence Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesi","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Chu","sequence":"additional","affiliation":[{"name":"Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual Science School of Medicine Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-8937","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"},{"name":"Shen Zhen Research Institute of Xiamen University  Shenzhen 518057 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-7286","authenticated-orcid":false,"given":"Gang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational Medicine Xiang An Biomedicine Laboratory School of Public Health Xiamen University  Xiamen 361102 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201901071"},{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aah5533"},{"key":"e_1_2_9_1_3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf9278"},{"key":"e_1_2_9_1_4","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202311505"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41322-6"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102281"},{"key":"e_1_2_9_2_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100748"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201601291"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01234"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2020.100085"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303714"},{"key":"e_1_2_9_4_4","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.abb9822"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00481"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaq1155"},{"key":"e_1_2_9_5_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b06731"},{"key":"e_1_2_9_5_4","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412187"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.adh2479"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaq0495"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aaz9519"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aay6626"},{"key":"e_1_2_9_8_3","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.abg9907"},{"key":"e_1_2_9_8_4","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11040311"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008262"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301916"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003327"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106865"},{"key":"e_1_2_9_11_3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq8545"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27379"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2015.09.011"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11080788"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-019-03865-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4946894"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0337-2"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-chembioeng-092320-120230"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202106506"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2020.06.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.3c01478"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000195323.46152.B3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4566-4"},{"key":"e_1_2_9_22_1","volume":"10","author":"Elk M.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-007-3068-8"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209413"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2018.06.07"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0196"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304840"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00848"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00263G"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300873"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310455"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10121404"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0351-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.aav7725"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24070-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2023.01.011"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119855"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202408613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T10:27:36Z","timestamp":1738146456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202408613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/smll.202408613"],"URL":"https:\/\/doi.org\/10.1002\/smll.202408613","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"assertion":[{"value":"2024-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2408613"}}