{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:07:15Z","timestamp":1789078035814,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3404204"],"award-info":[{"award-number":["2023YFC3404204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22077025"],"award-info":[{"award-number":["22077025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277054"],"award-info":[{"award-number":["22277054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2024202013"],"award-info":[{"award-number":["B2024202013"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2023202024"],"award-info":[{"award-number":["B2023202024"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["B2023202030"],"award-info":[{"award-number":["B2023202030"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M740968"],"award-info":[{"award-number":["2023M740968"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Glioblastoma (GBM) with highly immunosuppressive tumor microenvironment is a significant factor contributing to its treatment resistance and low survival rate. The activation of the transient receptor potential vanilloid 1 (TRPV1) ion channel, which is overexpressed on the endoplasmic reticulum (ER) of GBM cells, governs the control of multi\u2010organelle stress pathway branches to inhibit GBM expansion. Precise modulation of ER\u2010TRPV1 is considered an effective strategy for inhibition of GBM. As an effective intracellular and extracellular second messenger, nitric oxide (\u2022NO) activates the TRPV1 ion channel through nitrosylation of cysteine residues. However, the short lifespan and limited effective range of \u2022NO makes it challenging to achieve precise regulation of ER\u2010TRPV1. Herein, a biomimetic upconversion nanoassembly (M\u2010UCN\u2010T) is constructed, which encapsulates an organic \u2022NO donor and is coated with homologous tumor\u2010targeting cell membrane and ER\u2010targeting peptide. In response to near\u2010infrared light and glutathione, M\u2010UCN\u2010T releases \u2022NO in situ to activate the ER\u2010TRPV1 ion channels. This study developed a \u2022NO\u2010targeted release nanoplatform with stepwise targeting functions, which allow for the precise modulation of ER\u2010TPRV1 in GBM through in situ release of \u2022NO. This approach induces multi\u2010organelle stress signaling pathways, ultimately resulting in multi\u2010modal killing of tumor cells.<\/jats:p>","DOI":"10.1002\/smll.202408649","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T23:11:31Z","timestamp":1732576291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bionanoparticles with In Situ Nitric Oxide Release for Precise Modulation of ER\u2010TRPV1 Ion Channels in Multimodal Killing of Glioblastoma"],"prefix":"10.1002","volume":"21","author":[{"given":"Chaoqun","family":"Li","sequence":"first","affiliation":[{"name":"Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering Hebei University of Technology  Xiping Road Tianjin 300130 P. R. China"},{"name":"Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering  Ningbo 315201 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Peng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of High\u2010Performance Polymer Materials and Technology Department of Polymer Science &amp; Engineering School of Chemistry &amp; Chemical Engineering Nanjing University  Nanjing 210023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wang","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering  Ningbo 315201 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Gao","sequence":"additional","affiliation":[{"name":"Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering Hebei University of Technology  Xiping Road Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Hebei University of Technology  Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Hebei University of Technology  Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boying","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering Hebei University of Technology  Xiping Road Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering Hebei University of Technology  Xiping Road Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintao","family":"Shuai","sequence":"additional","affiliation":[{"name":"Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 510630 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fude","family":"Feng","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of High\u2010Performance Polymer Materials and Technology Department of Polymer Science &amp; Engineering School of Chemistry &amp; Chemical Engineering Nanjing University  Nanjing 210023 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1939-2265","authenticated-orcid":false,"given":"Chengfen","family":"Xing","sequence":"additional","affiliation":[{"name":"Innovation and Research Institute of Hebei University of Technology in Shijiazhuang, School of Health Sciences and Biomedical Engineering Hebei University of Technology  Xiping Road Tianjin 300130 P. R. China"},{"name":"School of Materials Science and Engineering Hebei University of Technology  Tianjin 300130 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052563"},{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254257"},{"key":"e_1_2_8_1_3","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.19"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.13549"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio821"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0701-x"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-01712-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2827"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.04.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301954"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c08503"},{"key":"e_1_2_8_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102506"},{"key":"e_1_2_8_5_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c13322"},{"key":"e_1_2_8_5_5","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010757"},{"key":"e_1_2_8_5_6","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00862-w"},{"key":"e_1_2_8_5_7","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202108435"},{"key":"e_1_2_8_5_8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b05292"},{"key":"e_1_2_8_5_9","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114763"},{"key":"e_1_2_8_5_10","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05192"},{"key":"e_1_2_8_5_11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c03701"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2827"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101705"},{"key":"e_1_2_8_6_3","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.019.20180015"},{"key":"e_1_2_8_6_4","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S274289"},{"key":"e_1_2_8_6_5","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202213765"},{"key":"e_1_2_8_6_6","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC02508G"},{"key":"e_1_2_8_6_7","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008507"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-022-1262-x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.09.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja017684a"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317578"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0701-x"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201606398"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801122"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202309972"},{"key":"e_1_2_8_10_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314536"},{"key":"e_1_2_8_10_4","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300012"},{"key":"e_1_2_8_10_5","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay5413"},{"key":"e_1_2_8_10_6","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311384"},{"key":"e_1_2_8_10_7","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12967"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c10517"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201802290"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202107155"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202207250"},{"key":"e_1_2_8_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202100692"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.06.004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0068-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310964"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11269-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9801723"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c09818"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.11.035"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.03.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2018.12.001"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.07.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06151-z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac544.2938"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.021"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.05.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.07.006"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202408649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202408649","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202408649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:31:04Z","timestamp":1772958664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202408649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/smll.202408649"],"URL":"https:\/\/doi.org\/10.1002\/smll.202408649","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]},"assertion":[{"value":"2024-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2408649"}}