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Developing new wound healing dressings capable of effectively regulating macrophage immune\u2010metabolic functions remains a pressing issue. Herein, a highly adhesive polyethylene glycol (PEG) hydrogel loaded with the Janus kinase 1 (JAK1) inhibitor Filgotinib (Fil@GEL) is prepared to modulate macrophage metabolic reprogramming and restore normal mitochondrial function.\u00a0Fil@GEL exhibits superior shear adhesion strength compared to commercially available tissue binder products, providing adequate adhesion for skin wound closure. Additionally, Fil@GEL exhibits the capacity to inhibit M1\u2010type macrophage polarization by suppressing the JAK\u2010STAT signaling pathway, and induces a metabolic shift in macrophages from aerobic glycolysis to oxidative phosphorylation, which results in decreased lactate production, reduced reactive oxygen species (ROS) levels, and the restoration of mitochondrial homeostasis. The Fil@GEL hydrogel significantly accelerates skin wound healing compared to the control group, reduces intra\u2010wound inflammation, and promotes collagen regeneration. In summary, this highly adhesive hydrogel demonstrates exceptional performance as a drug carrier, exerting immunometabolic modulation through firm wound adhesion and sustained filgotinib release, underscoring its substantial potential as an effective wound dressing.<\/jats:p>","DOI":"10.1002\/smll.202408791","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:02:48Z","timestamp":1734350568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-4282","authenticated-orcid":false,"given":"Jian","family":"Xie","sequence":"first","affiliation":[{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration &amp; Tongji Research Institute of Stomatology &amp; Department of Prosthodontics Shanghai Tongji Stomatological Hospital and Dental School Tongji University  Shanghai 200072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Biosis Healing Biological Technology Co., Ltd.  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