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Polymeric carriers are often used to tune the safety and efficacy profiles of these novel drugs. Despite their prevalence in pre\u2010clinical and clinical applications, non\u2010degradable materials present delivery challenges including diffusion\u2010limited release, frustrated phagocytosis, and limited clearance. In contrast, biodegradable polymeric systems provide a safer alternative in addition to displaying advantageous properties for the delivery of immunotherapies. In this review, discussion of polymers including poly(lactic\u2010co\u2010glycolic acid) (PLGA), poly(beta\u2010amino esters) (PBAEs), acetalated dextran (Ace\u2010DEX), chitosan, alginate, and hyaluronic acid (HA) as immunomodulatory biomaterial carriers suggest that a variety of systems can be used to generate tailored formulations for different therapeutic payloads and disease indications. These carrier systems can enhance the delivery of immunotherapies via tunable degradation rates, enhanced antigen\u2010presentation, and inherent immunomodulatory properties of the biomaterials, among other mechanisms. Polymers formulated for immunomodulatory applications can be synthetic, semi\u2010synthetic, or naturally derived. Therefore, it is crucial to consider the environmental impact of polymer sources, particle fabrication methods, and solvent usage to sustainably develop effective immunomodulatory therapies in this evolving field.<\/jats:p>","DOI":"10.1002\/smll.202409422","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T11:30:36Z","timestamp":1739705436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Biodegradable Polymers for Application as Robust Immunomodulatory Biomaterial Carrier Systems"],"prefix":"10.1002","volume":"22","author":[{"given":"Brian George","family":"Barbery","sequence":"first","affiliation":[{"name":"Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of Pharmacy University of North Carolina at Chapel Hill  Chapel Hill NC 27599 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