{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T10:14:14Z","timestamp":1793528054651,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T00:00:00Z","timestamp":1737849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The integration of hydrogen\u2010bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, their application in wearable and real\u2010time health monitoring remains largely unexplored, primarily due to the mechanical mismatch between the traditionally fragile HOFs particles and the softness of human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation and complex environmental conditions by integrating HOFs films with wavy bioelectrodes. This wearable biosensor demonstrates ultrasensitive detection capabilities, with a limit of detection of 49.64\u00a0nM, and accurately measures nutritional content in sweat while conforming to curved skin surfaces. The sensor's performance is comparable to those obtained using high\u2010performance liquid chromatography (HPLC). More strikingly, scratched HOFs films can be regenerated through a simple solvent rinsing process, enabling their reuse in the fabrication of new biosensors and offering a significant advantage over conventional sensing materials. This work has the potential to inspire the development of more flexible electronic devices, leveraging the structural adaptability and diversity of HOFs for personalized healthcare applications and real\u2010time health monitoring.<\/jats:p>","DOI":"10.1002\/smll.202409587","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:56:26Z","timestamp":1737946586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hydrogen\u2010Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics"],"prefix":"10.1002","volume":"21","author":[{"given":"Xue","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry. Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiru","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Human\u2010Machine Intelligence\u2010Synergy Systems Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen 518055 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bio\u2010based Material Science and Technology of Ministry of Education Northeast Forestry University  150040 Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Chunhua","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanghai University  Shanghai 200444 P. R. China"},{"name":"Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2398-399X","authenticated-orcid":false,"given":"Rong","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry. Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,26]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00290"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00730B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adj2763"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj9912"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00916-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-023-00032-w"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904664"},{"key":"e_1_2_7_8_1","volume":"32","author":"Wang C.","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM00337H"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800354"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902147"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305344"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12124"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313608"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01196"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02598"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00866E"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00155C"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsenergylett.1c02045"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202201768"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200126"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.2c01613"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04615-2"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb8308"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz0007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202000991"},{"key":"e_1_2_7_27_1","first-page":"1118","volume":"1","author":"Wang M.","year":"2020","journal-title":"IEEE Electron Device Lett."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw9906"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c07053"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08256"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44921-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006926"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06473"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay9842"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900342"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120801"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006444"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c00791"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202409587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T14:38:44Z","timestamp":1763735924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202409587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,26]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/smll.202409587"],"URL":"https:\/\/doi.org\/10.1002\/smll.202409587","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,26]]},"assertion":[{"value":"2024-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2409587"}}