{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:18:50Z","timestamp":1792653530187,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chemodynamic therapy (CDT) has garnered significant attention in the field of tumor therapy due to its ability to convert overexpressed hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) in tumors into highly toxic hydroxyl radicals\u00a0(\u2022OH) through metal ion\u2010mediated catalysis. However, the effectiveness of CDT is hindered by low catalyst efficiency, insufficient intra\u2010tumor H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    level, and excessive glutathione (GSH). In this study, a pH\/GSH dual responsive bimetallic nanocatalytic system (CuFeMOF@GOx@Mem) is developed by modifying red blood cell membranes onto glucose oxidase (GOx)\u2010loaded Fe\u2010Cu bimetallic MOFs, enhancing the efficacy of CDT through a triple\u2010enhanced way by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    self\u2010supply, catalysts self\u2010cycling, and GSH self\u2010elimination. Upon accumulation in tumor tissues facilitated by the red blood cell membrane, the GOx initiates a reaction with glucose to generate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and gluconic acid in situ. Subsequently, the reduced pH triggers the release of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    from CuFeMOF@GOx@Mem, which is immediately turned into Fe\n                    <jats:sup>2+<\/jats:sup>\n                    and Cu\n                    <jats:sup>+<\/jats:sup>\n                    by GSH, activating the Fe\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated Fenton reaction. More importantly, Cu\n                    <jats:sup>+<\/jats:sup>\n                    can also act as an accelerator of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \/Fe\n                    <jats:sup>2+<\/jats:sup>\n                    conversion, meanwhile, the generated Cu\n                    <jats:sup>2+<\/jats:sup>\n                    can be further reduced to Cu\n                    <jats:sup>+<\/jats:sup>\n                    by GSH. Consequently, sustained accumulation of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    as well as sustained elimination of GSH are achieved simultaneously, providing a unique approach for improving the anti\u2010tumor ability of CDT.\n                  <\/jats:p>","DOI":"10.1002\/smll.202409836","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T02:17:16Z","timestamp":1736561836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["A pH\/GSH Dual\u2010Responsive Triple Synergistic Bimetallic Nanocatalyst for Enhanced Tumor Chemodynamic Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0784-6047","authenticated-orcid":false,"given":"Lu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery The Second Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"},{"name":"Department of Tumor and Immunology in Precision Medical Institute The Second Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Tumor and Immunology in Precision Medical Institute The Second Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Tumor and Immunology in Precision Medical Institute The Second Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Tumor and Immunology in Precision Medical Institute The Second Affiliated Hospital Xi'an Jiaotong University  Xi'an 710000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"He","sequence":"additional","affiliation":[{"name":"The Breast Disease Diagnosis and Treatment Center The Second 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