{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:55:45Z","timestamp":1784750145921,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The present work reports the synthesis, characterization, and excited state photo\u2010physical studies of two copper(II) compounds, 1 &amp; 2, which show interference\u2010free emission with homocysteine (Hcy). Cu(II) complexes offer an orthogonal detection strategy involving fluorescence and electrochemical methods, paving the way for improved point\u2010of\u2010care diagnostics and early cardiovascular diseases intervention. The reduction\u2010induced emission enhancement (RIEE) of Cu complexes facilitates the fluorescence measurement of Hcy at physiological pH. The fluorogenic redox\u2010active 1 and 2 are deposited onto gold electrode surfaces to construct the electrochemical sensors 1@Au and 2@Au, respectively. Under specific alkaline conditions, a distinct and selective redox peak at 0.6\u00a0V (vs Ag\/AgCl) emerges for 1@Au upon interaction with homocysteine. Further, square wave voltammetry confirms the non\u2010interference of its congener (cysteine) even at high concentrations (200\u00a0\u00b5M) while detecting Hcy (5\u2013100\u00a0\u00b5M), demonstrating its potential for real\u2010world applications. The fabricated 1@Au exhibits excellent sensitivity of 31.88\u00a0\u00b5A\/\u00b5M, with an impressive detection limit of 2.26\u00a0nM, and a limit of quantification of 6.85\u00a0nM toward Hcy. The analytical applicability of the 1@Au is validated by quantifying Hcy levels in human blood plasma samples. The results highlighted the feasibility of the proposed technique as a rapid and portable monitoring of Hcy in diagnosing cardiovascular diseases (CVDs).<\/jats:p>","DOI":"10.1002\/smll.202409982","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T09:47:25Z","timestamp":1737625645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Redox\u2010Active Copper Complex for Orthogonal Detection of Homocysteine Involving Fluorescence and Electrochemical Techniques"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-7496","authenticated-orcid":false,"given":"Snehasish","family":"Debnath","sequence":"first","affiliation":[{"name":"Analytical &amp; Environmental Science Division and Centralized Instrument Facility CSIR\u2010CSMCRI  G. B. Marg Bhavnagar 364002 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriraja Subhasri","family":"Paramasivam","sequence":"additional","affiliation":[{"name":"Electrodics and Electrocatalysis Division CSIR\u2010CECRI  Karaikudi Tamil Nadu 630003 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjani","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Analytical &amp; Environmental Science Division and Centralized Instrument Facility CSIR\u2010CSMCRI  G. B. 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