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As a special antioxidant, molecular hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) is responsible for alleviating oxidative stress and associated inflammatory symptoms. However, in vivo continuous and efficient hydrogen accumulation is rather difficult to realize, thus frequent dosing is required to ensure the desired therapeutic effect. Herein, hydrogen\u2010bonded organic frameworks (HOFs) composites are rationally designed to achieve sustainable near\u2010infrared II (NIR\u2010II) photocatalytic hydrogen evolution reaction for relieving neuroinflammation in AD model mice. The HOFs composites mainly consist of three parts: building block porphyrin as the photocatalyst, DSM (NIR\u2010II\u2010absorbing pyridinium hemicyanine dye) as fluorescent emitter, and platinum nanoparticles as co\u2010catalyst. Under NIR\u2010II laser illumination, DSM acts as an energy transducer to activate porphyrin to produce reductive hydrogen in situ. Specially, porphyrin selectively binds with the accumulated Cu ions in A\u03b2 plaques and boosts H\n                    <jats:sub>2<\/jats:sub>\n                    evolution. KLVFFAED (KD8) is covalently grafted on the HOFs to improve the blood\u2013brain barrier permeability in vivo. This designed system exhibits an admirable therapeutic effect for relieving inflammation and recovering cognitive disorder in AD model mice, thus providing a new way for exploring HOFs used for sustainable hydrogen therapy.\n                  <\/jats:p>","DOI":"10.1002\/smll.202410063","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:56:44Z","timestamp":1741712204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hydrogen\u2010Bonded Organic Framework\u2010Based NIR\u2010II Activated Hydrogen Production for Treatment of Alzheimer's Disease Model Mice"],"prefix":"10.1002","volume":"21","author":[{"given":"Dongqin","family":"Yu","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science  Changchun Jilin 130022 P. R. 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