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Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative. The present study represents a dual\u2010functional scaffold that combines the neuroprotective and antioxidant capabilities of <jats:italic>Bacopa monnieri<\/jats:italic> extract with the mechanical and electrical characteristics of polycaprolactone (PCL)\u2010collagen fibers reinforced with multi\u2010walled carbon nanotubes (MWCNTs). The anisotropic alignment of MWCNTs enhances conductivity of the scaffold and provides directional cues for growth of the axons, while secondary metabolites of <jats:italic>Bacopa monnieri<\/jats:italic>, such as bacosides, promote neuronal survival and mitigate oxidative stress. In vitro, the scaffold lowers oxidative stress while promoting adhesion, proliferation, and differentiation of the neural cells. Utilizing an in vivo model of sciatic nerve crush damage, nerve regeneration is evaluated and improvements in axonal development, myelination, and recovery of motor\u2010sensory function are seen. This biofortified scaffold offers a sustainable substitute for traditional growth factors and pharmaceutical drugs by exploiting the synergistic effects of electrical conductivity and plant\u2010based bioactivity to promote peripheral nerve regeneration.<\/jats:p>","DOI":"10.1002\/smll.202410735","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:52:11Z","timestamp":1741855931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and <i>Bacopa Monnieri<\/i> for Accelerated Peripheral Nerve Regeneration"],"prefix":"10.1002","volume":"21","author":[{"given":"Souvik","family":"Ghosh","sequence":"first","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"},{"name":"Molecular Endocrinology Laboratory Department of Bioscience and Bioengineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"},{"name":"Biomaterials and Multiscale Mechanics Laboratory Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"},{"name":"Department of Ophthalmology and Visual Sciences SUNY Upstate Medical University  Syracuse NY 13210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"},{"name":"Biomaterials and Multiscale Mechanics Laboratory Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samrat","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Chitkara College of Pharmacy Chikara University  Rajpura Punjab 140401 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Roy","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology Laboratory Department of Bioscience and Bioengineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-7307","authenticated-orcid":false,"given":"Debrupa","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Centre for Nanotechnology Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"},{"name":"Biomaterials and Multiscale Mechanics Laboratory Department of Metallurgical and Materials Engineering Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.265540"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/400_2009_19"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17531934241242002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1609"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169206"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13071105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.973301"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.863969"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1299166"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1332-11.2011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48534-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00534"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.07.087"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12061256"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2015.56342"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02394.1988"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1965"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1141827"},{"key":"e_1_2_8_20_1","first-page":"4","volume":"13","author":"Twaij B. 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