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In this study, an innovative Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @ZIF\u20108\u2010RVC (FZR) dual\u2010responsive nanoplatform is introduced that integrates magnetic targeting with pH\u2010sensitive, sustained drug release to overcome these limitations. The FZR nanoplatform encapsulates ropivacaine (RVC) within the ZIF\u20108\u2010coated Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    core, enabling precise and prolonged analgesia at the injury site through magnetic guidance and acid\u2010triggered release. In vitro and in vivo assessments indicate that FZR achieves high drug loading, sustained release in acidic environments, and excellent biocompatibility, significantly extending analgesic effects in chronic nerve injury models while minimizing systemic exposure. Behavioral tests and molecular analyses in LBP rat models confirm that FZR effectively suppresses pain\u2010related neuronal activity and central sensitization markers. This dual\u2010responsive nanoplatform FZR offers a safe, long\u2010lasting, and targeted therapeutic approach, holding strong potential for advancing pain relief in LBP and related neuropathic pain conditions.\n                  <\/jats:p>","DOI":"10.1002\/smll.202410874","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:02:06Z","timestamp":1740124926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Dual\u2010Responsive Fe\u2083O\u2084@ZIF\u20108 Nanoplatform Combining Magnetic Targeting and pH Sensitivity for Low Back Pain Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2412-8223","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics the Affiliated Hospital of Qingdao University Qingdao University  Qingdao 266003 P. R. 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