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The quantitative control of H\n                    <jats:sub>2<\/jats:sub>\n                    S release is crucial for effective the rapeutic interventions; however, traditional researchon H\n                    <jats:sub>2<\/jats:sub>\n                    S therapy frequently utilizes static release models and neglects the dynamic nature of blood flow. In this study, we propose a novel slow\u2010release in\u2010situ H\n                    <jats:sub>2<\/jats:sub>\n                    S release model that leverages the dynamic hydrolysis of H\n                    <jats:sub>2<\/jats:sub>\n                    S donorswithin the bloodstream. Calcium sulfide nanoparticles (CaS NPs) withmicrosolubility characteristics exhibit continuous H\n                    <jats:sub>2<\/jats:sub>\n                    S release, surpassing 24 h at normal blood flow velocities. The extended\u2010release profile demonstrates superior potential in aligning with the bell\u2010shapedpharmacological effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S, compared to NaHS. Moreover, we synthesisedrare earth\u2010doped CaS NPs (CaS: Eu\n                    <jats:sup>2+<\/jats:sup>\n                    , Sm\n                    <jats:sup>3+<\/jats:sup>\n                    NPs) tha texhibit persistent luminescence, enabling visualisation of the continuous H\n                    <jats:sub>2<\/jats:sub>\n                    S release in trials. Our results demonstrate that lowdose CaS: Eu\n                    <jats:sup>2+<\/jats:sup>\n                    , Sm\n                    <jats:sup>3+<\/jats:sup>\n                    NPs significantly reduces seizureduration to 1.2\u00a0\u00b1\u00a00.7 minutes, while high dose effectively suppresses colontumor growth with a tumor inhibition rate of 54%. Remarkably, these findings closely resemble endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S levels in treating epilepsy and tumors. This innovative slow\u2010release, in\u2010situ H\n                    <jats:sub>2<\/jats:sub>\n                    S the rapeutic approach via hydrolysis rejuvenates the development of H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010basedtherapeutics.\n                  <\/jats:p>","DOI":"10.1002\/smll.202410909","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T01:41:04Z","timestamp":1737510064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In Situ Slow\u2010Release Hydrogen Sulfide Therapeutics for Advanced Disease Treatments"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5521-3115","authenticated-orcid":false,"given":"Yiqing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Institute of Neuroscience Key Laboratory of Neurogenetics and Channelopathies of Guangdong 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