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Herein, a gas\u2010assisted PTT strategy is designed to link near\u2010infrared heptamethine cyanine (Cy7) with self\u2010immolative phenyl thiocarbonate (PTC), a hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donor through a disulfide bond, creating a small\u2010molecule photosensitizer (Cy7\u2010SS\u2010PTC) that can self\u2010assemble into nanoparticles (NPs) without stabilizers. Upon internalized by cancer cells, Cy7\u2010SS\u2010PTC NPs respond to elevated glutathione levels, and simultaneously release Cy7 and H\n                    <jats:sub>2<\/jats:sub>\n                    S via a cascade reaction. The released Cy7 reassembles into nanoaggregates, generating hyperthermia under 808\u00a0nm light irradiation, and then binds to albumin, producing strong near\u2010infrared fluorescence to track tumors for precise treatment. The released H\n                    <jats:sub>2<\/jats:sub>\n                    S not only disrupts the mitochondrial respiratory chain, blocks ATP production, and suppresses HSP70 overexpression to amplify the efficacy of low\u2010temperature PTT regions but also curbs proinflammatory cytokines in high\u2010temperature PTT zones, delivering powerful tumor ablation with minimal inflammation. This small\u2010molecule\u2010based \u201cH\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010assisted PTT\u201d strategy optimizes the current PTT and validates its potential clinical application.\n                  <\/jats:p>","DOI":"10.1002\/smll.202411242","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:57:07Z","timestamp":1740121027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Self\u2010Assembly of H\n                    <sub>2<\/sub>\n                    S\u2010Generating Photosensitizer for Gas\u2010Assisted Synergistic Photothermal Therapy"],"prefix":"10.1002","volume":"21","author":[{"given":"Hao","family":"Kong","sequence":"first","affiliation":[{"name":"College of Material Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 P. R. 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