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However, achieving accurate and rapid monitoring of ppb\u2010level fractional exhaled nitric oxide (FeNO) at room temperature remains a significant challenge. Herein, ultrathin porphyrin metal\u2013organic framework (MOF) sheets are selected to assemble with supramolecularly functionalized graphene sheets through hydrogen bonding and electrostatic interaction with 6\u00a0nm thickness. The resulting porphyrin MOF\/graphene sheet\u2010on\u2010sheet nanohybrid is designed as a chemiresistive NO sensor which exhibits superior gas sensing performance at room temperature including an ultralow practical limit of detection (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    \/\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>g<\/jats:sub>\n                    \u00a0=\u00a01.047, 5\u00a0ppb NO), reliable repeatability, excellent selectivity against other exhaled gases, and relative long\u2010term stability. Mechanism study indicates that the prominent NO sensing performance is attributed to the ordered framework of active sites of ferric\u2010pyrrole (Fe\u2500N\n                    <jats:sub>4<\/jats:sub>\n                    ) sites and less than 10\u00a0nm thick sheet\u2010on\u2010sheet heterojunction structure in the nanohybrid. The potential clinical utility of the obtained sensors is validated by exhalation tests toward exhalation samples from healthy individuals and asthma patients, respectively. This work provides an effective strategy of developing MOF\u2010based room temperature ppb\u2010level chemiresistive NO sensors for practical FeNO monitoring.\n                  <\/jats:p>","DOI":"10.1002\/smll.202411264","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T03:22:39Z","timestamp":1740885759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Practical ppb\u2010Level Room Temperature Chemiresistive Nitric Oxide Sensing Assembly Based on Ultrathin Thick Porphyrin MOF Nanosheets"],"prefix":"10.1002","volume":"21","author":[{"given":"Zijing","family":"Fu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Optical Information Materials and Technology Institute of Electronic Paper Displays National Center for International Research on Green Optoelectronics South China Academy of Advanced Optoelectronics South China Normal University  Guangzhou 510006 P. 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