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Routine liver diagnosis by recording magnetic resonance (MR) images in the presence of a liver\u2010directing contrast agent (CA) can recognize any abnormalities early. However, the clinically approved liver\u2010specific Gd(III)\u2010based CAs are of great concern for bio\u2010safety. In fact, several medical agencies have restricted the usage of such CAs. Thus, to develop non\u2010Gd\u2010based biocompatible CAs for liver imaging, a thermodynamically stable and kinetically inert nonaquated six\u2010coordinate paramagnetic Fe(III)\u2010complex (1) is confined within a biocompatible porous silica nanoparticle of size about 18\u00a0nm. Such entrapment has boosted the longitudinal relaxivity value of Complex <jats:bold>1<\/jats:bold> (<jats:italic>r<\/jats:italic><jats:sub>1<\/jats:sub> = 0.59\u00a0\u00d7 10<jats:sup>\u22123<\/jats:sup> <jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup>) upto 9 times to 5.36\u00a0\u00d7 10<jats:sup>\u22123<\/jats:sup> <jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup>, which further increased to 10.83\u00a0\u00d7 10<jats:sup>\u22123<\/jats:sup> <jats:sc>m<\/jats:sc><jats:sup>\u22121<\/jats:sup>s<jats:sup>\u22121<\/jats:sup> in the presence of 0.67\u00a0\u00d7 10<jats:sup>\u22123<\/jats:sup>\u00a0<jats:sc>m<\/jats:sc> concentration of serum albumin protein. Surface functionalization of the nanoparticle with hydrophobic <jats:italic>p<\/jats:italic>\u2010methoxybenzamide (<jats:bold>C1<\/jats:bold>@SiO<jats:sub>2<\/jats:sub>\u2010PMBA\u2010NP) facilitates HepG2 cell internalization as evinced by in vitro fluorescent images and flow cytometry analyses. Time\u2010dependent contrast changes in the liver MR images recorded on C57BL\/6 mice in a preclinical MRI instrument establish the applicability of the biocompatible <jats:bold>C1<\/jats:bold>@SiO<jats:sub>2<\/jats:sub>\u2010PMBA\u2010NP as the T<jats:sub>1<\/jats:sub>\u2010weighted liver\u2010directing CA for magnetic resonance imaging (MRI).<\/jats:p>","DOI":"10.1002\/smll.202411465","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T10:39:13Z","timestamp":1755081553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver\u2010Directing Fe(III)\u2010Based MRI Contrast Agent"],"prefix":"10.1002","volume":"21","author":[{"given":"Geetanjali","family":"Deka","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Guwahati Assam 781039 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisha","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioengineering Indian Institute of Technology Guwahati  Guwahati Assam 781039 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of NMR All India Institute of Medical Sciences  Ansari Nagar New Delhi 110029 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandna","family":"Singh","sequence":"additional","affiliation":[{"name":"Centre for Medical Biotechnology Maharshi Dayanand University  Rohtak Haryana 124001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Mohan","sequence":"additional","affiliation":[{"name":"Centre for Medical Biotechnology Maharshi Dayanand University  Rohtak Haryana 124001 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-0139","authenticated-orcid":false,"given":"S. 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