{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:51:53Z","timestamp":1789735913340,"version":"4.0.1"},"reference-count":80,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is marked by the buildup of neurotoxic A\u03b2 plaques.In this study, EGCG\u2010dopamine\u2010tryptophan nanoparticles (EDTNPs) that prevent A\u03b2 fibrillization, aid plaque clearance, improve oxidative balance, reduce neuronal damage, and enhance cell survival through protective effects are synthesized. To boost neuroprotection further, BDNF, a neurotrophic factor that promotes neuronal growth, are loaded onto the EDTNPs (B\u2010EDTNPs), leading to a notable increase in the protection of neuronal cells. B\u2010EDTNPs exhibit a pronounced neuroprotective effect against FF and A\u03b2 (1\u201042) fibril\u2010induced toxicity in SH\u2010SY5Y neuroblastoma cells, enhancing cell viability from \u2248 37% to 92% and from 48% to 88%, respectively; which is \u224820% and \u224821% higher compared to EDTNPs at 24\u00a0h duration. Studies involving animal models further demonstrate that B\u2010EDTNPs effectively dislodge amyloid aggregates in vivo, leading to a significant reduction in plaque accumulation (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). This intervention not only promotes the clearance of toxic aggregates but also noticeably suppresses the NF\u2010\u03baB and TNF\u2010\u03b1 inflammatory biomarkers, aiding in restoring cognitive function and enhancing behavioral outcomes in treated BALB\/c AD animal models. The theoretical studies show that NP components interact with A\u03b2 (1\u201342) polypeptides, promoting disaggregation. This highlights a novel approach for creating effective nanocomposites that combine A\u03b2 inhibitors with antioxidants to target AD.\n                  <\/jats:p>","DOI":"10.1002\/smll.202411701","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T03:05:28Z","timestamp":1751339128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["BDNF Loaded Amino Acid\u2010Catecholamine Hybrid Nanoparticles as Curative Agents Against Cognitive Decline in Alzheimer's Disease"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4162-8432","authenticated-orcid":false,"given":"Himanshu Sekhar","family":"Panda","sequence":"first","affiliation":[{"name":"Brain and Supramolecular Nanotherapeutics Laboratory Chemical Biology Unit Institute of Nano Science and Technology  Sector\u201081, Knowledge City, Sahibzada Ajit Singh Nagar Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrunali D.","family":"Dhokne","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular NeuroTherapeutics Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Raebareli Uttar Pradesh 226002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Thakur","sequence":"additional","affiliation":[{"name":"Brain and Supramolecular Nanotherapeutics Laboratory Chemical Biology Unit Institute of Nano Science and Technology  Sector\u201081, Knowledge City, Sahibzada Ajit Singh Nagar Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology University  Gandhinagar Gujarat 382355 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Datusalia","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular NeuroTherapeutics Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)  Raebareli Uttar Pradesh 226002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-7491","authenticated-orcid":false,"given":"Jiban Jyoti","family":"Panda","sequence":"additional","affiliation":[{"name":"Brain and Supramolecular Nanotherapeutics Laboratory Chemical Biology Unit Institute of Nano Science and Technology  Sector\u201081, Knowledge City, Sahibzada Ajit Singh Nagar Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7]]},"reference":[{"key":"e_1_2_8_1_1","volume-title":"Number of adults with dementia to exceed 150m by 2050, study finds","author":"Gregory A.","year":"2022"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1221"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179941"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08823"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.02.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26102897"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(03)00031-5"},{"key":"e_1_2_8_9_1","first-page":"111","volume":"104","author":"Nguyen P. 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