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However, their potential toxicity due to long\u2010term accumulation in the brain and bones raises safety concerns. In contrast, non\u2010metallic MRI CAs, which can produce a nuclear magnetic resonance effect, show great promise in MRI applications due to their adaptable structure and function, good biocompatibility, and excellent biodegradability. Nevertheless, the development of non\u2010metallic MRI CAs is slow due to the inherent low magnetic sensitivity of organic compounds, their rapid metabolism, and susceptibility to reduction. Designing effective multifunctional organic compounds for high\u2010sensitivity MRI remains a challenge. In this discussion, the mechanisms of various non\u2010metallic MRI CAs are explored and an overview of their current status, highlighting both their advantages and potential drawbacks, is provided. 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